2,4-Dimethyl-4-phenyltetrahydrofuran

INCI: 2,4-DIMETHYL-4-PHENYLTETRAHYDROFURAN

CAS Number
82461-14-1 (also 99343-90-5 for (2R,4R)-rel isomer)
Function
Fragrance (perfuming agent); also known as Rhubafurane
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted as fragrance ingredient; also evaluated as synthetic flavoring substance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Cramer Class III material; metabolite predicted reactive in silico; possibly persistent in environment (28.5% biodegradation at 28 days, OECD 301B); screening-level PEC/PNEC initially >1 but refined to <1

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Concern Level: Moderate

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is 2,4-Dimethyl-4-phenyltetrahydrofuran safe in cosmetics?

Cramer Class III material; metabolite predicted reactive in silico; possibly persistent in environment (28.5% biodegradation at 28 days, OECD 301B); screening-level PEC/PNEC initially >1 but refined to <1 The EU classifies 2,4-Dimethyl-4-phenyltetrahydrofuran as "permitted". Safety rating: MODERATE.

Is 2,4-Dimethyl-4-phenyltetrahydrofuran allowed in the EU?

2,4-Dimethyl-4-phenyltetrahydrofuran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,4-Dimethyl-4-phenyltetrahydrofuran do in cosmetics?

2,4-Dimethyl-4-phenyltetrahydrofuran functions as: Fragrance (perfuming agent); also known as Rhubafurane. It is classified as a cosmetic ingredient in our database. CAS number: 82461-14-1 (also 99343-90-5 for (2R,4R)-rel isomer).

What is the Margin of Safety for 2,4-Dimethyl-4-phenyltetrahydrofuran?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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