Is 2,6-Dimethyl-4-heptanone safe in cosmetics?
2,6-Dimethyl-4-heptanone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
2,6-Dimethyl-4-heptanone
Also known as: Diisobutylketone (4-Heptanone, 2,6-dimethyl-), 4-01-00-03360, BRN 1743163, Caswell No. 355B, sec-Diisopropyl acetone (+11 more)
INCI: 2,6-DIMETHYL-4-HEPTANONE
2,6-Dimethyl-4-heptanone (CAS 108-83-8) is a cosmetic cosmetic ingredient functioning as Fragrance / perfuming; also functions industrially as a solvent. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-83-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,6-Dimethyl-4-heptanone is classified GHS Danger (H226, H335, H305, H320, H336, H370, H402, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance / perfuming; also functions industrially as a solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,6-dimethylheptan-4-one
InChIKey
PTTPXKJBFFKCEK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not individually regulated as a cosmetic ingredient; fragrance exemption applies. Also has industrial solvent uses
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,6-Dimethyl-4-heptanone.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Exposure to high concentrations could cause lowering of consciousness.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2,6-Dimethyl-4-heptanone across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; STOT SE 3
Hazard Statements
- H226 Flammable liquid and vapour
- H335 May cause respiratory irritation
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 10.0%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
0713
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
... Eye and skin contact may produce slight to moderate irritation.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
302
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2,6-DIMETHYL-4-HEPTANONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/235 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIISOBUTYL KETONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/235 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Film former
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2,6-Dimethyl-4-heptanone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Diisobutylketone (4-Heptanone, 2,6-dimethyl-)
4-01-00-03360
BRN 1743163
Caswell No. 355B
sec-Diisopropyl acetone
sym-Diisopropylacetone
2,6-Dimethylheptanone
EINECS 203-620-1
FEMA No. 3537
Valerone
2,6-Dimethyl-heptan-4-on
2,6-Dimetil-eptan-4-one
Diisobutilchetone
Di-isobutylcetone
Diisobutylketon
UNII-V52W30H1BU
Chemical Function
Fragrance
Solvent
Flavouring and nutrient
Binder
Regulatory Lists
IFRA Transparency
Europe
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Arts and crafts/Office supplies - general arts and crafts supplies; Europe
Arts and crafts/Office supplies - general arts and crafts supplies; Europe
Europe; Specialty occupational products
Europe; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182186
Frequently Asked Questions
Is 2,6-Dimethyl-4-heptanone allowed in the EU?
2,6-Dimethyl-4-heptanone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Dimethyl-4-heptanone do in cosmetics?
2,6-Dimethyl-4-heptanone functions as: Fragrance / perfuming; also functions industrially as a solvent. It is classified as a cosmetic ingredient in our database. CAS number: 108-83-8.
Is 2,6-Dimethyl-4-heptanone used outside cosmetics?
2,6-Dimethyl-4-heptanone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,6-Dimethyl-4-heptanone have different safety status in cosmetics vs industrial chemicals?
2,6-Dimethyl-4-heptanone is classified GHS Danger (H226, H335, H305, H320, H336, H370, H402, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2,6-Dimethyl-4-heptanone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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