Moderate Cosmetic Ingredient NOAEL Data GHS Classified

2,6-Dimethyl-4-heptanone

INCI: 2,6-DIMETHYL-4-HEPTANONE

CAS Number
108-83-8
Function
Fragrance / perfuming; also functions industrially as a solvent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not individually regulated as a cosmetic ingredient; fragrance exemption applies. Also has industrial solvent uses

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for 2,6-Dimethyl-4-heptanone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 714 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1429 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOEL 50 mg/kg bw/day oral rat oral REACH
NOAEL 2000 mg/kg bw/day oral rat oral REACH
NOEL 50 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Exposure to high concentrations could cause lowering of consciousness.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Primary industrial use as a coating solvent, dispersant, and paint stripper . Solvent properties may enhance penetration of co-formulated ingredients. Verify purity grade is cosmetic-appropriate. Potential CNS effects at high exposures (industrial context, not cosmetic)

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is 2,6-Dimethyl-4-heptanone safe in cosmetics?

Primary industrial use as a coating solvent, dispersant, and paint stripper . Solvent properties may enhance penetration of co-formulated ingredients. Verify purity grade is cosmetic-appropriate. Potential CNS effects at high exposures (industrial context, not cosmetic) The EU classifies 2,6-Dimethyl-4-heptanone as "permitted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.

Is 2,6-Dimethyl-4-heptanone allowed in the EU?

2,6-Dimethyl-4-heptanone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,6-Dimethyl-4-heptanone do in cosmetics?

2,6-Dimethyl-4-heptanone functions as: Fragrance / perfuming; also functions industrially as a solvent. It is classified as a cosmetic ingredient in our database. CAS number: 108-83-8.

What is the Margin of Safety for 2,6-Dimethyl-4-heptanone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2,6-Dimethyl-4-heptanone?

The NOAEL (No Observed Adverse Effect Level) for 2,6-Dimethyl-4-heptanone is 714 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check 2,6-Dimethyl-4-heptanone compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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