3-Propylidenephthalide
INCI: 3-PROPYLIDENEPHTHALIDE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 3-Propylidenephthalide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 6.55 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 6.55 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Sensitization Profile
Contact sensitization data for 3-Propylidenephthalide based on clinical patch test studies and IFRA standards.
Source: EU 2023/1545; SCCS
Expert Verdict
GHS classified as Irritant; IFRA category-specific maximum use levels must be observed (e.g., 0.1% for leave-on face and body creams)
Regulatory Flags
Frequently Asked Questions
Is 3-Propylidenephthalide safe in cosmetics?
GHS classified as Irritant; IFRA category-specific maximum use levels must be observed (e.g., 0.1% for leave-on face and body creams) The EU classifies 3-Propylidenephthalide as "prohibited". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is 3-Propylidenephthalide allowed in the EU?
3-Propylidenephthalide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Propylidenephthalide do in cosmetics?
3-Propylidenephthalide functions as: Fragrance with celery and herbal character; used as flavor modifier. It is classified as a cosmetic ingredient in our database. CAS number: 17369-59-4.
What is the Margin of Safety for 3-Propylidenephthalide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 3-Propylidenephthalide?
The NOAEL (No Observed Adverse Effect Level) for 3-Propylidenephthalide is 6.55 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check 3-Propylidenephthalide compliance across multiple jurisdictions:
Related Ingredients
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