Is 3-Tert-Butyl-2-Methoxypyrazine safe in cosmetics?
3-Tert-Butyl-2-Methoxypyrazine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
3-Tert-Butyl-2-Methoxypyrazine
Also known as: 2-sec-Butyl-3-methoxypyrazine, Pyrazine, 2-methoxy-3-(1-methylpropyl)-, 2-Methoxy-3-(1-methylpropyl)pyrazine, EINECS 246-050-9, FEMA No. 3433 (+3 more)
INCI: 3-TERT-BUTYL-2-METHOXYPYRAZINE
3-Tert-Butyl-2-Methoxypyrazine (CAS 24168-70-5) is a cosmetic cosmetic ingredient functioning as Fragrance with extremely potent green bell pepper aroma and ultra-low odor. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 24168-70-5 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance with extremely potent green bell pepper aroma and ultra-low odor threshold of 1-2 ppt in water
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-butan-2-yl-3-methoxypyrazine
InChIKey
QMQDJVIJVPEQHE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no specific FDA cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Tert-Butyl-2-Methoxypyrazine.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
791
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-sec-BUTYL-3-METHOXYPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHOXY-3-sec-BUTYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHOXY-3-(1-METHYLPROPYL)PYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 3-Tert-Butyl-2-Methoxypyrazine.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2-sec-Butyl-3-methoxypyrazine
Pyrazine, 2-methoxy-3-(1-methylpropyl)-
2-Methoxy-3-(1-methylpropyl)pyrazine
EINECS 246-050-9
FEMA No. 3433
2-Methoxy-3-sec-butylpyrazine
Pyrazine, 2-sec-butyl-3-methoxy-
UNII-62UR370ONE
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL94514
Frequently Asked Questions
Is 3-Tert-Butyl-2-Methoxypyrazine allowed in the EU?
3-Tert-Butyl-2-Methoxypyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Tert-Butyl-2-Methoxypyrazine do in cosmetics?
3-Tert-Butyl-2-Methoxypyrazine functions as: Fragrance with extremely potent green bell pepper aroma and ultra-low odor threshold of 1-2 ppt in water. It is classified as a cosmetic ingredient in our database. CAS number: 24168-70-5.
Is 3-Tert-Butyl-2-Methoxypyrazine used outside cosmetics?
3-Tert-Butyl-2-Methoxypyrazine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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