Is 3-Tert-Butyl-2-Methoxypyrazine safe in cosmetics?
3-Tert-Butyl-2-Methoxypyrazine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
3-Tert-Butyl-2-Methoxypyrazine
Also known as: 2-sec-Butyl-3-methoxypyrazine, Pyrazine, 2-methoxy-3-(1-methylpropyl)-, 2-Methoxy-3-(1-methylpropyl)pyrazine, EINECS 246-050-9, FEMA No. 3433 (+3 more)
INCI: 3-TERT-BUTYL-2-METHOXYPYRAZINE
3-Tert-Butyl-2-Methoxypyrazine (CAS 24168-70-5) is a cosmetic cosmetic ingredient functioning as Fragrance with extremely potent green bell pepper aroma and ultra-low odor. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 24168-70-5 →
Function
Fragrance with extremely potent green bell pepper aroma and ultra-low odor threshold of 1-2 ppt in water
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-butan-2-yl-3-methoxypyrazine
InChIKey
QMQDJVIJVPEQHE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no specific FDA cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Tert-Butyl-2-Methoxypyrazine.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
791
Source: WHO/JECFA
JECFA Evaluation
2-sec-BUTYL-3-METHOXYPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: WHO/JECFA
JECFA Evaluation
2-METHOXY-3-sec-BUTYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: WHO/JECFA
JECFA Evaluation
2-METHOXY-3-(1-METHYLPROPYL)PYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for 3-Tert-Butyl-2-Methoxypyrazine — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2-sec-Butyl-3-methoxypyrazine
Pyrazine, 2-methoxy-3-(1-methylpropyl)-
2-Methoxy-3-(1-methylpropyl)pyrazine
EINECS 246-050-9
FEMA No. 3433
2-Methoxy-3-sec-butylpyrazine
Pyrazine, 2-sec-butyl-3-methoxy-
UNII-62UR370ONE
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL94514
Frequently Asked Questions
Is 3-Tert-Butyl-2-Methoxypyrazine allowed in the EU?
3-Tert-Butyl-2-Methoxypyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Tert-Butyl-2-Methoxypyrazine do in cosmetics?
3-Tert-Butyl-2-Methoxypyrazine functions as: Fragrance with extremely potent green bell pepper aroma and ultra-low odor threshold of 1-2 ppt in water. It is classified as a cosmetic ingredient in our database. CAS number: 24168-70-5.
Is 3-Tert-Butyl-2-Methoxypyrazine used outside cosmetics?
3-Tert-Butyl-2-Methoxypyrazine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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