4-Ethylguaiacol

INCI: 4-ETHYLGUAIACOL

CAS Number
2785-89-9
Function
Fragrance (warm, spicy-medicinal, guaiacol character)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted by FDA; RIFM Expert Panel concludes safe as described

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Cramer Class I ingredient; not genotoxic (Ames negative via guaiacol read-across); not phototoxic. IFRA category-specific maximum concentrations apply (e.g., 0.13% in lip products, 0.039% in axillae products).

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Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is 4-Ethylguaiacol safe in cosmetics?

Cramer Class I ingredient; not genotoxic (Ames negative via guaiacol read-across); not phototoxic. IFRA category-specific maximum concentrations apply (e.g., 0.13% in lip products, 0.039% in axillae products). The EU classifies 4-Ethylguaiacol as "permitted". Safety rating: GOOD.

Is 4-Ethylguaiacol allowed in the EU?

4-Ethylguaiacol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Ethylguaiacol do in cosmetics?

4-Ethylguaiacol functions as: Fragrance (warm, spicy-medicinal, guaiacol character). It is classified as a cosmetic ingredient in our database. CAS number: 2785-89-9.

What is the Margin of Safety for 4-Ethylguaiacol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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