Is 4-Ethylguaiacol safe in cosmetics?
4-Ethylguaiacol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
4-Ethylguaiacol
Also known as: EINECS 220-500-4, FEMA No. 2436, Homocresol, 4-Hydroxy-3-methoxy ethylbenzene, 1-Hydroxy-2-methoxy-4-ethylbenzene (+1 more)
INCI: 4-ETHYLGUAIACOL
4-Ethylguaiacol (CAS 2785-89-9) is a cosmetic cosmetic ingredient functioning as Fragrance (warm, spicy-medicinal, guaiacol character). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
View industrial chemical safety profile for CAS 2785-89-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (warm, spicy-medicinal, guaiacol character)
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; RIFM Expert Panel concludes safe as described
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Ethylguaiacol.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-Ethylguaiacol.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
EINECS 220-500-4
FEMA No. 2436
Homocresol
4-Hydroxy-3-methoxy ethylbenzene
1-Hydroxy-2-methoxy-4-ethylbenzene
UNII-C9NFD83BJ5
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Cleaning products and household care - air freshener; Europe
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186900
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
4-ETHYLGUAIACOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 4-Ethylguaiacol allowed in the EU?
4-Ethylguaiacol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Ethylguaiacol do in cosmetics?
4-Ethylguaiacol functions as: Fragrance (warm, spicy-medicinal, guaiacol character). It is classified as a cosmetic ingredient in our database. CAS number: 2785-89-9.
Is 4-Ethylguaiacol used outside cosmetics?
4-Ethylguaiacol also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4-Ethylguaiacol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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