4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate

INCI: 4-FLUORO-6-METHYL-M-PHENYLENEDIAMINE SULFATE

CAS Number
873397-34-3
Function
Hair dyeing oxidative hair dye coupler/precursor
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under FDA coal-tar hair dye exemption (21 CFR 73/74); must bear caution labeling and patch test instructions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Strong sensitizer with high cross-reactivity risk; fluorine substitution modifies toxicity profile versus parent PPD. Requires allergic reaction warning, patch test instructions before each use, and restriction from eyebrow/eyelash application.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate safe in cosmetics?

Strong sensitizer with high cross-reactivity risk; fluorine substitution modifies toxicity profile versus parent PPD. Requires allergic reaction warning, patch test instructions before each use, and restriction from eyebrow/eyelash application. The EU classifies 4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate as "prohibited". Safety rating: MODERATE.

Is 4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate allowed in the EU?

4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate do in cosmetics?

4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate functions as: Hair dyeing oxidative hair dye coupler/precursor. It is classified as a cosmetic ingredient in our database. CAS number: 873397-34-3.

What is the Margin of Safety for 4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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