Also known as: Vanillyl isobutyrate, Propanoic acid, 2-methyl-, 4-formyl-2-methoxyphenyl ester, EINECS 243-956-6, FEMA No. 3754, 4-Formyl-2-methoxyphenyl 2-methylpropanoate (+7 more)
INCI: 4-FORMYL-2-METHOXYPHENYL ISOBUTYRATE
4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) (CAS 20665-85-4) is a cosmetic cosmetic ingredient functioning as Fragrance with sweet/vanilla olfactory profile. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 20665-85-4 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate).
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | subchronic | ECHA |
Pre-calculated NOAEL → SED → MoS audit trail for 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) across SCCS product categories, with measured dermal absorption where available.
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 109 | 0 | 590 | 590 | non-sensitizer |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Preliminary editorial summary for 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) by CAS number or substance name.
Same-CAS public records found in pharmaceutical and food safety data.
Same-CAS rows from the pharmaceutical spoke database.
Same-CAS food additive or FDA GRAS records from the core public database.
4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) functions as: Fragrance with sweet/vanilla olfactory profile. It is classified as a cosmetic ingredient in our database. CAS number: 20665-85-4.
The NOAEL (No Observed Adverse Effect Level) for 4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) is =1000 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ECHA.
4-Formyl-2-Methoxyphenyl Isobutyrate (Vanillin Isobutyrate) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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