Moderate Cosmetic Ingredient

4-Nitro-O-Phenylenediamine HCl

INCI: 4-NITRO-O-PHENYLENEDIAMINE DIHYDROCHLORIDE

CAS Number
6219-77-8
Function
Oxidative hair dye (produces brown, red, blonde shades)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Restricted; CIR-assessed with restrictions for use as hair dye

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Strong sensitizer with in vitro mutagenic potential; associated with liver toxicity (hepatocellular hypertrophy) in animal studies with NOAEL established at 15 mg/kg/day by SCCP evaluation.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 4-Nitro-O-Phenylenediamine HCl safe in cosmetics?

Strong sensitizer with in vitro mutagenic potential; associated with liver toxicity (hepatocellular hypertrophy) in animal studies with NOAEL established at 15 mg/kg/day by SCCP evaluation. The EU classifies 4-Nitro-O-Phenylenediamine HCl as "prohibited". Safety rating: MODERATE.

Is 4-Nitro-O-Phenylenediamine HCl allowed in the EU?

4-Nitro-O-Phenylenediamine HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Nitro-O-Phenylenediamine HCl do in cosmetics?

4-Nitro-O-Phenylenediamine HCl functions as: Oxidative hair dye (produces brown, red, blonde shades). It is classified as a cosmetic ingredient in our database. CAS number: 6219-77-8.

What is the Margin of Safety for 4-Nitro-O-Phenylenediamine HCl?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 4-Nitro-O-Phenylenediamine HCl compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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