Is 7-Ethylbicyclooxazolidine safe in cosmetics?
7-Ethylbicyclooxazolidine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
7-Ethylbicyclooxazolidine
Also known as: Oxazolidine E (1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-) (Oxazolidine-E), Oxazolidine-E, 1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-, 1-Aza-5-ethyl-3,7-dioxabicyclo(3.3.0)octane, EINECS 231-810-4 (+8 more)
INCI: 7-ETHYLBICYCLOOXAZOLIDINE
7-Ethylbicyclooxazolidine (CAS 7747-35-5) is a cosmetic cosmetic ingredient functioning as Preservative (antimicrobial; formaldehyde releaser). NOAEL 15 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7747-35-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
7-Ethylbicyclooxazolidine is classified GHS Danger (H315, H317, H318, H319, H332, H335, H412) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Preservative (antimicrobial; formaldehyde releaser)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.1%
US US Status
permitted
US Notes
Permitted; no specific FDA restriction; CIR has reviewed formaldehyde releasers as a class with safety at concentration limits
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 7-Ethylbicyclooxazolidine.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 7-Ethylbicyclooxazolidine across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex V — Permitted Preservatives
Max: 0.3%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (V - Preservatives)
Max: 0.003.
BRIN Brazil/India Cosmetics
Brazil: Permitted Preservative · max 0,3%
India: Permitted Preservative · max 0.003
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | permitted_preservative | 0.3 | all cosmetics except oral and mucous membrane contact products |
| BR | permitted_preservative | 0.3 | Not in oral products; not in products contacting mucous membranes |
| ASEAN | permitted_preservative | 0.3% | All products |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Preservative
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 7-Ethylbicyclooxazolidine.
Regulatory Flags
preservative
eu_cosing_listed
Known Synonyms
Oxazolidine E (1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-) (Oxazolidine-E)
Oxazolidine-E
1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-
1-Aza-5-ethyl-3,7-dioxabicyclo(3.3.0)octane
EINECS 231-810-4
5-Ethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane
Bioban CS 1246
Chemtan A 60
Neosyn TX
Paramel TX 50
Zoldine ZE
Oxazolidine E
UNII-20E75SVO7A
Chemical Function
Preservative
Biocide
Regulatory Lists
Europe; Personal care
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183106
Frequently Asked Questions
Is 7-Ethylbicyclooxazolidine allowed in the EU?
7-Ethylbicyclooxazolidine EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does 7-Ethylbicyclooxazolidine do in cosmetics?
7-Ethylbicyclooxazolidine functions as: Preservative (antimicrobial; formaldehyde releaser). It is classified as a cosmetic ingredient in our database. CAS number: 7747-35-5.
Is 7-Ethylbicyclooxazolidine used outside cosmetics?
7-Ethylbicyclooxazolidine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 7-Ethylbicyclooxazolidine have different safety status in cosmetics vs industrial chemicals?
7-Ethylbicyclooxazolidine is classified GHS Danger (H315, H317, H318, H319, H332, H335, H412) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Compliance Tools
Check 7-Ethylbicyclooxazolidine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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