Is Acetaldehyde Phenethyl Propyl Acetal safe in cosmetics?
Acetaldehyde Phenethyl Propyl Acetal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Acetaldehyde Phenethyl Propyl Acetal
Also known as: Acetal R, Acetaldehyde phenylethyl propyl acetal, Acetaldehyde propyl phenylethyl acetal, EINECS 231-327-9, FEMA No. 2004 (+4 more)
INCI: ACETALDEHYDE PHENETHYL PROPYL ACETAL
Acetaldehyde Phenethyl Propyl Acetal (CAS 7493-57-4) is a cosmetic cosmetic ingredient functioning as Fragrance / Perfuming (green note). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Fragrance / Perfuming (green note)
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
EC Number
231-327-9
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetaldehyde Phenethyl Propyl Acetal.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Acetaldehyde Phenethyl Propyl Acetal based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: SCCS Opinion
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
310 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [267] Epstein WL (1979): Report to RIFM, 9 March, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3375 | - | - |
| HRIPT | - | 0 | 310 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Acetaldehyde Phenethyl Propyl Acetal — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Acetal R
Acetaldehyde phenylethyl propyl acetal
Acetaldehyde propyl phenylethyl acetal
EINECS 231-327-9
FEMA No. 2004
Pepital
1-Phenethoxy-1-propoxyethane
Propyl phenethyl acetal
UNII-U811MB854I
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ACETALDEHYDE PHENETHYL PROPYL ACETAL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Acetaldehyde Phenethyl Propyl Acetal allowed in the EU?
Acetaldehyde Phenethyl Propyl Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetaldehyde Phenethyl Propyl Acetal do in cosmetics?
Acetaldehyde Phenethyl Propyl Acetal functions as: Fragrance / Perfuming (green note). It is classified as a cosmetic ingredient in our database. CAS number: 7493-57-4.
Is Acetaldehyde Phenethyl Propyl Acetal used outside cosmetics?
Acetaldehyde Phenethyl Propyl Acetal also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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