4-Methylpentane-2,3-Dione

INCI: 4-METHYLPENTANE-2,3-DIONE

CAS Number
7493-58-5
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically restricted by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Vicinal diketone structurally related to diacetyl, which is associated with bronchiolitis obliterans via inhalation. Topical cosmetic use at trace fragrance levels is low risk, but aerosolized products warrant caution.

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

fragrance-component fda_food_additive

Frequently Asked Questions

Is 4-Methylpentane-2,3-Dione safe in cosmetics?

Vicinal diketone structurally related to diacetyl, which is associated with bronchiolitis obliterans via inhalation. Topical cosmetic use at trace fragrance levels is low risk, but aerosolized products warrant caution. The EU classifies 4-Methylpentane-2,3-Dione as "permitted". Safety rating: MODERATE.

Is 4-Methylpentane-2,3-Dione allowed in the EU?

4-Methylpentane-2,3-Dione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Methylpentane-2,3-Dione do in cosmetics?

4-Methylpentane-2,3-Dione functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 7493-58-5.

What is the Margin of Safety for 4-Methylpentane-2,3-Dione?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is 4-Methylpentane-2,3-Dione in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4-Methylpentane-2,3-Dione in your formulation.