Is Acetoacetoxyethoxy Methacrylate safe in cosmetics?
Acetoacetoxyethoxy Methacrylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Acetoacetoxyethoxy Methacrylate
Also known as: Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propen-1-yl)oxy)ethyl ester, Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propenyl)oxy)ethyl ester, 2-[Methacryloyloxy]ethyl acetoacetate, 2-(Acetoacetoxy)ethyl methacrylate, EINECS 244-311-1 (+3 more)
INCI: ACETOACETOXYETHOXY METHACRYLATE
Acetoacetoxyethoxy Methacrylate (CAS 21282-97-3) is a cosmetic cosmetic ingredient functioning as Film forming agent used in nail products and hair fixatives. Reported NOAEL =1000 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 21282-97-3 →
Auto-generated CPSR Part A draft with source citations
Function
Film forming agent used in nail products and hair fixatives
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR evaluated within the methacrylate/acrylate monomer group; permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetoacetoxyethoxy Methacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Acetoacetoxyethoxy Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Film former
Expert Verdict
Expert safety assessment and concern-level summary for Acetoacetoxyethoxy Methacrylate.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acetoacetoxyethoxy Methacrylate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propen-1-yl)oxy)ethyl ester
Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propenyl)oxy)ethyl ester
2-[Methacryloyloxy]ethyl acetoacetate
2-(Acetoacetoxy)ethyl methacrylate
EINECS 244-311-1
2-(Methacryloyloxy)ethyl acetoacetate
UNII-6L3EW3HZF2
Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester
Chemical Function
Film former
Chemical reaction regulator
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188313
Frequently Asked Questions
Is Acetoacetoxyethoxy Methacrylate allowed in the EU?
Acetoacetoxyethoxy Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetoacetoxyethoxy Methacrylate do in cosmetics?
Acetoacetoxyethoxy Methacrylate functions as: Film forming agent used in nail products and hair fixatives. It is classified as a cosmetic ingredient in our database. CAS number: 21282-97-3.
What is the NOAEL for Acetoacetoxyethoxy Methacrylate?
The NOAEL (No Observed Adverse Effect Level) for Acetoacetoxyethoxy Methacrylate is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ECHA.
Is Acetoacetoxyethoxy Methacrylate used outside cosmetics?
Acetoacetoxyethoxy Methacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acetoacetoxyethoxy Methacrylate compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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