Is HEMA Acetoacetate safe in cosmetics?
HEMA Acetoacetate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
HEMA Acetoacetate
Also known as: Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propen-1-yl)oxy)ethyl ester, Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propenyl)oxy)ethyl ester, 2-[Methacryloyloxy]ethyl acetoacetate, 2-(Acetoacetoxy)ethyl methacrylate, EINECS 244-311-1 (+3 more)
INCI: HEMA ACETOACETATE
HEMA Acetoacetate (CAS 21282-97-3) is a cosmetic cosmetic ingredient functioning as Film forming (nail enhancement). Reported NOAEL =1000 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 21282-97-3 →
Function
Film forming (nail enhancement)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted - CIR concluded safe as used in nail enhancement products when labeled to avoid skin contact
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HEMA Acetoacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for HEMA Acetoacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Film former
Editorial summary
Preliminary editorial summary for HEMA Acetoacetate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HEMA Acetoacetate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propen-1-yl)oxy)ethyl ester
Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propenyl)oxy)ethyl ester
2-[Methacryloyloxy]ethyl acetoacetate
2-(Acetoacetoxy)ethyl methacrylate
EINECS 244-311-1
2-(Methacryloyloxy)ethyl acetoacetate
UNII-6L3EW3HZF2
Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester
Chemical Function
Film former
Chemical reaction regulator
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188313
Frequently Asked Questions
Is HEMA Acetoacetate allowed in the EU?
HEMA Acetoacetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does HEMA Acetoacetate do in cosmetics?
HEMA Acetoacetate functions as: Film forming (nail enhancement). It is classified as a cosmetic ingredient in our database. CAS number: 21282-97-3.
What is the NOAEL for HEMA Acetoacetate?
The NOAEL (No Observed Adverse Effect Level) for HEMA Acetoacetate is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ECHA.
Is HEMA Acetoacetate used outside cosmetics?
HEMA Acetoacetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check HEMA Acetoacetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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