Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 1,2-Hexanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 700 mg/kg bw/day | dermal | rat | dermal | REACH |
Expert Verdict
Versatile diol with moderate antimicrobial activity used as solvent, texture modifier, and preservative booster in cosmetic formulations. Works best as part of a combined hurdle approach rather than as a sole preservative, with recommended use concentrations of 0.5–3.0% to minimize irritation potential.
Regulatory Flags
Frequently Asked Questions
Is 1,2-Hexanediol safe in cosmetics?
Versatile diol with moderate antimicrobial activity used as solvent, texture modifier, and preservative booster in cosmetic formulations. Works best as part of a combined hurdle approach rather than as a sole preservative, with recommended use concentrations of 0.5–3.0% to minimize irritation potential. The EU classifies 1,2-Hexanediol as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is 1,2-Hexanediol allowed in the EU?
1,2-Hexanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,2-Hexanediol do in cosmetics?
1,2-Hexanediol functions as: solvent, preservative booster, antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 6920-22-5.
What is the Margin of Safety for 1,2-Hexanediol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 1,2-Hexanediol?
The NOAEL (No Observed Adverse Effect Level) for 1,2-Hexanediol is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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