Is DIPROPYLENE GLYCOL safe in cosmetics?
DIPROPYLENE GLYCOL has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
DIPROPYLENE GLYCOL
Also known as: Propanol, oxybis-, Dowanol DPG, Caswell No. 399E, EINECS 246-770-3, EPA Pesticide Chemical Code 068604 (+4 more)
DIPROPYLENE GLYCOL (CAS 25265-71-8) is a cosmetic cosmetic ingredient functioning as solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 25265-71-8 →
Auto-generated CPSR Part A draft with source citations
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: low toxicity; grouped with PG family; safe as used at 1-10%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for DIPROPYLENE GLYCOL.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
GROUP; SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
8 property records from structured ingredient metadata.
baby_pediatric
{"cas_number": "CAS-FUNC-7", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Functional ingredient - generally safe", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern"…
cost_pricing
{"cost_tier": "budget", "estimated_cost_per_kg_usd_low": "5", "estimated_cost_per_kg_usd_high": "10", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global", "bulk_discount_threshold_kg": "500", "seasonal_price_variation": "low", "commodity_or_specialty": "commodity", "substitute_ingredients": "Propylene Glycol",…
deodorant
{"cas_number": "25265-71-8", "ingredient_class": "other", "mechanism_of_action": "other", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "0", "odor_reduction_pct": "0", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "astringency_level": "vari…
humectant
{"cas_number": "25265-71-8", "ingredient_class": "humectant/polyol", "molecular_weight_Da": "134.17", "chemical_type": "polyol", "water_binding_mechanism": "hydrogen_bonding", "water_holding_capacity_g_per_g": "0.3-0.5", "hygroscopicity_at_50_RH": "moderate", "hygroscopicity_at_80_RH": "good", "NMF_component": "no", "NMF_percentage_natural": "0", "TEWL_reduction_pct": "8-15", "skin_hydration_incre…
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe; solvent", "source": "dermatology literature"}
sensory
{"silky": "light", "smooth, glides easily": "smooth, wet", "dry-touch, non-greasy": "hydrated, soft", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "high", "no": "no", "yes": "no", "1.40": "1.44", "transparent": "transparent", "colorless": "colorless", "excellent": "good", "light": "light", "synthetic": "synthetic"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "solvent", "skin_benefit_secondary": "humectant", "mechan…
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "partial", "soluble_in": "water, ethanol, propylene glycol", "insoluble_in": "oils", "log_p": "-0.5", "melting_point_c": "-40", "appearance": "clear liquid", "source": "Dow"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Adhesion/cohesion promoter
Degradant/impurity
Deodorizer
Fragrance
No specific technical function
Plasticizer
Processing aids not otherwise specified
Softener and conditioner
Solubility enhancer
Regulatory List Membership (6)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for DIPROPYLENE GLYCOL.
Regulatory Flags
eu_children_restricted
epa_safer_alternative
ifra_fragrance
jecfa_concern
Known Synonyms
Propanol, oxybis-
Dowanol DPG
Caswell No. 399E
EINECS 246-770-3
EPA Pesticide Chemical Code 068604
Oxybispropanol
4-Oxa-2,6-heptandiol
1,1'-Oxybis(2-propanol)
UNII-E107L85C40
Chemical Function
Solvent
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is DIPROPYLENE GLYCOL allowed in the EU?
DIPROPYLENE GLYCOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DIPROPYLENE GLYCOL do in cosmetics?
DIPROPYLENE GLYCOL functions as: solvent. It is classified as a cosmetic ingredient in our database. CAS number: 25265-71-8.
Is DIPROPYLENE GLYCOL used outside cosmetics?
DIPROPYLENE GLYCOL also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check DIPROPYLENE GLYCOL compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
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