Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Erythrosin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 800 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | swine | Subchronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | gerbil | Carcinogenicity | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | gerbil | Chronic | COSMOS_DB |
Expert Verdict
Synthetic red colorant with severe regulatory restrictions; banned from US cosmetics since 1990 and restricted in EU to toothpaste at maximum 0.0025% due to thyroid tumor findings in animal studies.
Regulatory Flags
Frequently Asked Questions
Is Erythrosin safe in cosmetics?
Synthetic red colorant with severe regulatory restrictions; banned from US cosmetics since 1990 and restricted in EU to toothpaste at maximum 0.0025% due to thyroid tumor findings in animal studies. The EU classifies Erythrosin as "restricted". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.
Is Erythrosin allowed in the EU?
Erythrosin EU regulatory status: restricted. Maximum allowed concentration: 0.0025% in toothpaste only. This is based on EU Regulation 1223/2009 and its amendments.
What does Erythrosin do in cosmetics?
Erythrosin functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 16423-68-0.
What is the Margin of Safety for Erythrosin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Erythrosin?
The NOAEL (No Observed Adverse Effect Level) for Erythrosin is 800 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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