Good Cosmetic Ingredient NOAEL Data

CI 45405

CAS Number
18472-87-2
Function
Colorant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status prohibited
US Notes Not listed as an approved FDA D&C or FD&C color additive for cosmetics in the US. Closely related CI 45410 (Phloxine B) is approved as D&C Red No. 28.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for CI 45405. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

CI 45405 is permitted in the EU but prohibited for cosmetic use in the US.

⚠️
Concern Level: Low

Regulatory Flags

not-for-eye-products not-fda-approved synthetic-dye xanthene-dye halogenated-fluorescein acid-red-98 eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is CI 45405 safe in cosmetics?

CI 45405 is permitted in the EU but prohibited for cosmetic use in the US. The EU classifies CI 45405 as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is CI 45405 allowed in the EU?

CI 45405 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 45405 do in cosmetics?

CI 45405 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 18472-87-2.

What is the Margin of Safety for CI 45405?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 45405?

The NOAEL (No Observed Adverse Effect Level) for CI 45405 is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

Compliance Tools

Check CI 45405 compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

CI 45220
Good
CI 12085 (Pigment Red 4 / D&C Red No. 36)
Good
CI 74180
Good
CI 16185
Moderate
CI 26100
Moderate
Browse all 30,000+ ingredients →
📱

Is CI 45405 in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CI 45405 in your formulation.

Ingredient Decoder MoS Calculator