Is L-Alanyl-L-Glutamine safe in cosmetics?
L-Alanyl-L-Glutamine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
L-Alanyl-L-Glutamine
Also known as: Ala-gln, N(2)-L-Alanyl-L-glutamine, Dipeptiven, Dipeptamin, UNII-U5JDO2770Z (+7 more)
INCI: ALANYL GLUTAMINE
L-Alanyl-L-Glutamine (CAS 39537-23-0) is a cosmetic cosmetic ingredient functioning as Humectant, skin conditioning, emollient. NOAEL 833 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 39537-23-0 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, skin conditioning, emollient
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S)-5-amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoic acid
InChIKey
HJCMDXDYPOUFDY-WHFBIAKZSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Generally recognized as safe amino acid dipeptide; no specific FDA restrictions for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for L-Alanyl-L-Glutamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for L-Alanyl-L-Glutamine across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
2121
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
L-ALANYL-L-GLUTAMINE | 2012 | No safety concern at current levels of intake when used as a flavouring agent | TRS 974-JECFA 76 | FAS 67 JECFA 76
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for L-Alanyl-L-Glutamine.
Regulatory Flags
amino-acid
dipeptide
humectant
skin-conditioning
COSMOS-compatible
fda_food_additive
jecfa_safe
Known Synonyms
Ala-gln
N(2)-L-Alanyl-L-glutamine
Dipeptiven
Dipeptamin
UNII-U5JDO2770Z
Alanyl-Glutamine
L-Ala-L-Gln
AQ zwitterion
L-Ala-L-Gln zwitterion
L-alanyl-L-glutamine zwitterion
alanylglutamine zwitterion
Ala-Gln zwitterion
Chemical Function
Humectant
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
Canada; pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ALANYL GLUTAMINE
ChEMBL ID
CHEMBL3707366
Max Phase
3
Adverse Event Associations
3
Frequently Asked Questions
Is L-Alanyl-L-Glutamine allowed in the EU?
L-Alanyl-L-Glutamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Alanyl-L-Glutamine do in cosmetics?
L-Alanyl-L-Glutamine functions as: Humectant, skin conditioning, emollient. It is classified as a cosmetic ingredient in our database. CAS number: 39537-23-0.
Is L-Alanyl-L-Glutamine used outside cosmetics?
L-Alanyl-L-Glutamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check L-Alanyl-L-Glutamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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