Is Ethyl Palmitate safe in cosmetics?
Ethyl Palmitate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Ethyl Palmitate
Also known as: EINECS 211-064-6, FEMA No. 2451, UNII-IRD3M534ZM, Ethyl N-hexadecanoate, Ethyl cetylate (+7 more)
INCI: ETHYL PALMITATE
Ethyl Palmitate (CAS 628-97-7) is a cosmetic cosmetic ingredient functioning as Emollient, skin conditioning, perfuming. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 628-97-7 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, skin conditioning, perfuming
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
ethyl hexadecanoate
InChIKey
XIRNKXNNONJFQO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No restrictions; CIR assessed alkyl esters including palmitate esters as safe in cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Palmitate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Palmitate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Tonnage data confidential
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
39
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL HEXADECANOATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/21 | See TRS 868-JECFA 46/64
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL PALMITATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/21 | See TRS 868-JECFA 46/64
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Softener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Palmitate.
Regulatory Flags
emollient
ester
CIR-approved
non-greasy
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Palmitate by CAS number or substance name.
Studies
3
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
EINECS 211-064-6
FEMA No. 2451
UNII-IRD3M534ZM
Ethyl N-hexadecanoate
Ethyl cetylate
Ethyl hexadecanoate (ethyl palmitate)
Ethylpalmitate
FEMA 2451
HEXADECANOIC ACID,ETHYL ESTER MFC18 H36 O2
Palmitic acid ethyl ester
Palmitic acid, ethyl ester (8CI)
WE(2:0/16:0)
Chemical Function
Softener and conditioner
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
Europe
detected; Europe; Personal care - body adhesive
Australia; Food and drug - smoking-related products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Cons electronics mech appliances and machinery; detected; Europe
Cleaning products and household care - air freshener; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561042
Frequently Asked Questions
Is Ethyl Palmitate allowed in the EU?
Ethyl Palmitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Palmitate do in cosmetics?
Ethyl Palmitate functions as: Emollient, skin conditioning, perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 628-97-7.
Is Ethyl Palmitate used outside cosmetics?
Ethyl Palmitate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Palmitate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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