Androstadienone

INCI: ANDROSTADIENONE

CAS Number
4075-07-4
Function
Perfuming/Fragrance (pheromone-like compound)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically prohibited in cosmetics; note that the related compound androstenedione is a Schedule III controlled substance. Androstadienone is structurally distinct but regulators may question steroid derivatives.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Endogenous steroid with documented neuroendocrine and pheromone-like activity; testosterone metabolite with potential endocrine activity; high dermal absorption presents systemic exposure risk; no formal cosmetic safety assessment published; significant regulatory risk for future restrictions as endocrine disruptor screening intensifies.

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Concern Level: High

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is Androstadienone safe in cosmetics?

Endogenous steroid with documented neuroendocrine and pheromone-like activity; testosterone metabolite with potential endocrine activity; high dermal absorption presents systemic exposure risk; no formal cosmetic safety assessment published; significant regulatory risk for future restrictions as endocrine disruptor screening intensifies. The EU classifies Androstadienone as "prohibited". Safety rating: MODERATE.

Is Androstadienone allowed in the EU?

Androstadienone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Androstadienone do in cosmetics?

Androstadienone functions as: Perfuming/Fragrance (pheromone-like compound). It is classified as a cosmetic ingredient in our database. CAS number: 4075-07-4.

What is the Margin of Safety for Androstadienone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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