Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Calcium Propionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 943 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 943 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 300 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 300 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 400 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| dose_tested | 400 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
Expert Verdict
Calcium Propionate is restricted in the EU for use as a preservative unless added to Annex V. If used for a non-preservative function with incidental preservation, regulatory justification is complex and carries compliance risk. Permitted in the US but not formally established for cosmetic dermal use.
Regulatory Flags
Frequently Asked Questions
Is Calcium Propionate safe in cosmetics?
Calcium Propionate is restricted in the EU for use as a preservative unless added to Annex V. If used for a non-preservative function with incidental preservation, regulatory justification is complex and carries compliance risk. Permitted in the US but not formally established for cosmetic dermal use. The EU classifies Calcium Propionate as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Calcium Propionate allowed in the EU?
Calcium Propionate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Propionate do in cosmetics?
Calcium Propionate functions as: Preservative (antimicrobial). It is classified as a cosmetic ingredient in our database. CAS number: 4075-81-4.
What is the Margin of Safety for Calcium Propionate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Propionate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Propionate is 943 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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