Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for Anisaldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 ppm | oral | rat | oral | REACH |
| NOAEL | 10000 ppm | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 10000 ppm | oral | rat | oral | REACH |
Expert Verdict
Not phototoxic (confirmed by RIFM) ; photoallergenicity not yet fully evaluated (RIFM in vitro program ongoing) ; high dermal absorption (80%) means systemic exposure calculations are critical in CPSR; IFRA-restricted material - verify compliance with applicable IFRA category limits
Regulatory Flags
Frequently Asked Questions
Is Anisaldehyde safe in cosmetics?
Not phototoxic (confirmed by RIFM) ; photoallergenicity not yet fully evaluated (RIFM in vitro program ongoing) ; high dermal absorption (80%) means systemic exposure calculations are critical in CPSR; IFRA-restricted material - verify compliance with applicable IFRA category limits The EU classifies Anisaldehyde as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.
Is Anisaldehyde allowed in the EU?
Anisaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Anisaldehyde do in cosmetics?
Anisaldehyde functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 123-11-5.
What is the Margin of Safety for Anisaldehyde?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Anisaldehyde?
The NOAEL (No Observed Adverse Effect Level) for Anisaldehyde is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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