Poor Cosmetic Ingredient NOAEL Data

Antimony Potassium Tartrate

INCI: ANTIMONY POTASSIUM TARTRATE

CAS Number
28300-74-5
Function
Depilatory (historical use; no longer permitted)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not explicitly listed as a banned cosmetic ingredient by FDA, but antimony compounds are considered toxic heavy metals. Use would likely trigger adulteration concerns under FD&C Act ยง601(a).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Antimony Potassium Tartrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1686 other oral rat oral REACH
NOAEL 3 2104 1992 mouse inhalation REACH
NOAEL 3 2104 1992 rat inhalation REACH

Expert Verdict

Prohibited in EU and US due to systemic toxicity (cardiotoxic, hepatotoxic) and classification as a possible carcinogen (IARC Group 2B for antimony trioxide). Subject to Chemicals Prohibition Ordinance in Germany. Not permitted in any cosmetic formulation.

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Concern Level: High

Frequently Asked Questions

Is Antimony Potassium Tartrate safe in cosmetics?

Prohibited in EU and US due to systemic toxicity (cardiotoxic, hepatotoxic) and classification as a possible carcinogen (IARC Group 2B for antimony trioxide). Subject to Chemicals Prohibition Ordinance in Germany. Not permitted in any cosmetic formulation. The EU classifies Antimony Potassium Tartrate as "prohibited". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.

Is Antimony Potassium Tartrate allowed in the EU?

Antimony Potassium Tartrate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Antimony Potassium Tartrate do in cosmetics?

Antimony Potassium Tartrate functions as: Depilatory (historical use; no longer permitted). It is classified as a cosmetic ingredient in our database. CAS number: 28300-74-5.

What is the Margin of Safety for Antimony Potassium Tartrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Antimony Potassium Tartrate?

The NOAEL (No Observed Adverse Effect Level) for Antimony Potassium Tartrate is 1686 other based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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