Is ANTHRAQUINONE safe in cosmetics?
ANTHRAQUINONE has a safety rating of "MODERATE" in our database. EU status: restricted. 1 toxicological study endpoint(s) are available in our database.
ANTHRAQUINONE
Also known as: 9,10-Anthraquinone, Anthracene, 9,10-dihydro-9,10-dioxo-, Anthrapel, Bis-alkylamino anthraquinone, Caswell No. 052A (+6 more)
ANTHRAQUINONE (CAS 84-65-1) is a cosmetic cosmetic ingredient functioning as Not Reported. NOAEL 2 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max II/1603. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 84-65-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
ANTHRAQUINONE is classified GHS Danger (H317, H350, H320, H351, H373, H400, H410) in the chemicals database but is restricted in EU cosmetics at max II/1603.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not Reported
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
anthracene-9,10-dione
InChIKey
RZVHIXYEVGDQDX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/1603
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for ANTHRAQUINONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1.44 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
May cause mechanical irritation.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for ANTHRAQUINONE across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
101
Evaluation Year
2011
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Carc. 1B
Hazard Statements
- H350 May cause cancer
Inserted via ATP: ATP10
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1603
(EU) 2019/831
CMR: Carcinogenic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Anthraquinone | Group 2B: Possibly carcinogenic to humans | Volume 101: (2012) Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-water
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Anthraquinone | TR-494: Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) (2005 ) | 02/17/04 | Some Evidence | Clear Evidence | Clear Evidence | Clear Evidence | Under the conditions of these 2-year feed studies, there was some evidence of carcinogenic activity of anthraquinone in male F344/N rats based on increased incide
Source: NTP Technical Reports
ICSC Safety Card
1605
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritates... skin.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Intermediate
No specific technical function
Pigment
Surface modifier
Regulatory List Membership (4)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for ANTHRAQUINONE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
prop65
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ANTHRAQUINONE by CAS number or substance name.
Studies
14
Lowest NOAEL
1.44 mg/kg bw/day
Highest NOAEL
391 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
ToxRefDB_ToxRefDB_v3_pod.csv
Known Synonyms
9,10-Anthraquinone
Anthracene, 9,10-dihydro-9,10-dioxo-
Anthrapel
Bis-alkylamino anthraquinone
Caswell No. 052A
EINECS 201-549-0
EPA Pesticide Chemical Code 122701
9,10-Anthrachinon
UNII-030MS0JBDO
9,10-quinone
Az-Q
Chemical Function
Dye
Surface modifier
Intermediate
Pigment
Regulatory Lists
banned; Europe; Personal care
Indirect additives food contact (10/2018)
detected; ground_water; MN Chemical Screening
active_ingredient; Europe; Pesticides
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
OEHHA Proposition 65 (3/2019)
Europe; Other direct contact consumer goods; residue
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ANTHRAQUINONE
ChEMBL ID
CHEMBL55659
Frequently Asked Questions
Is ANTHRAQUINONE allowed in the EU?
ANTHRAQUINONE EU regulatory status: restricted. Maximum allowed concentration: II/1603. This is based on EU Regulation 1223/2009 and its amendments.
What does ANTHRAQUINONE do in cosmetics?
ANTHRAQUINONE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 84-65-1.
What is the NOAEL for ANTHRAQUINONE?
The NOAEL (No Observed Adverse Effect Level) for ANTHRAQUINONE is =1.44 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is ANTHRAQUINONE used outside cosmetics?
ANTHRAQUINONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does ANTHRAQUINONE have different safety status in cosmetics vs industrial chemicals?
ANTHRAQUINONE is classified GHS Danger (H317, H350, H320, H351, H373, H400, H410) in the chemicals database but is restricted in EU cosmetics at max II/1603.
Compliance Tools
Check ANTHRAQUINONE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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