Moderate Cosmetic Ingredient NOAEL Data GHS Classified

ANTHRAQUINONE

CAS Number
84-65-1
Function
Not Reported
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Restricted
EU Max Conc. II/1603
๐Ÿ‡บ๐Ÿ‡ธ US Status Not specifically regulated

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Toxicological Studies

6 study endpoints found for ANTHRAQUINONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL ca.2 mg/kg bw/day oral rat oral REACH
NOAEL 15 ppm oral rat oral REACH
LOAEL 50 mg/kg bw/day oral rat oral REACH
NOAEL 62 other oral - oral REACH
NOAEL 80 other oral rat oral REACH
NOAEL >1100 other oral mouse oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
May cause mechanical irritation.

Expert Verdict

ANTHRAQUINONE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1603.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is ANTHRAQUINONE safe in cosmetics?

ANTHRAQUINONE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1603. The EU classifies ANTHRAQUINONE as "Restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.

Is ANTHRAQUINONE allowed in the EU?

ANTHRAQUINONE EU regulatory status: Restricted. Maximum allowed concentration: II/1603. This is based on EU Regulation 1223/2009 and its amendments.

What does ANTHRAQUINONE do in cosmetics?

ANTHRAQUINONE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 84-65-1.

What is the NOAEL for ANTHRAQUINONE?

The NOAEL (No Observed Adverse Effect Level) for ANTHRAQUINONE is ca.2 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.

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