Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Benzyl Butyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 21 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 21 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 2229.9 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 25 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 other | oral | rat | oral | REACH |
Expert Verdict
Cramer Class I (low concern). Not genotoxic, not phototoxic. NOAEL 14.5 mg/kg/day (repeated dose); NOAEL 100 mg/kg/day (developmental)
Regulatory Flags
Frequently Asked Questions
Is Benzyl Butyrate safe in cosmetics?
Cramer Class I (low concern). Not genotoxic, not phototoxic. NOAEL 14.5 mg/kg/day (repeated dose); NOAEL 100 mg/kg/day (developmental) The EU classifies Benzyl Butyrate as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is Benzyl Butyrate allowed in the EU?
Benzyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzyl Butyrate do in cosmetics?
Benzyl Butyrate functions as: Perfuming / Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-37-7.
What is the Margin of Safety for Benzyl Butyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Benzyl Butyrate?
The NOAEL (No Observed Adverse Effect Level) for Benzyl Butyrate is 21 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Benzyl Butyrate compliance across multiple jurisdictions:
Related Ingredients
Is Benzyl Butyrate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Benzyl Butyrate in your formulation.