Is Benzyl Isobutyrate safe in cosmetics?
Benzyl Isobutyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Benzyl Isobutyrate
Also known as: Propanoic acid, 2-methyl-, phenylmethyl ester, Benzyl isobutanoate, Benzyl 2-methyl propionate, Benzyl 2-methylpropionate, BRN 1869299 (+6 more)
INCI: BENZYL ISOBUTYRATE
Benzyl Isobutyrate (CAS 103-28-6) is a cosmetic cosmetic ingredient functioning as Perfuming / Fragrance ingredient. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 103-28-6 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming / Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
203-095-9
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR group assessment concluded safe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzyl Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Benzyl Isobutyrate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Benzyl Isobutyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Benzyl Isobutyrate by CAS number or substance name.
Studies
18
Lowest NOAEL
46 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Propanoic acid, 2-methyl-, phenylmethyl ester
Benzyl isobutanoate
Benzyl 2-methyl propionate
Benzyl 2-methylpropionate
BRN 1869299
EINECS 203-095-9
FEMA No. 2141
NSC 406201
Phenylmethyl 2-methylpropanoate
Benzylester kyseliny isomaselne
UNII-P98PE45V9M
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561355
Frequently Asked Questions
Is Benzyl Isobutyrate allowed in the EU?
Benzyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzyl Isobutyrate do in cosmetics?
Benzyl Isobutyrate functions as: Perfuming / Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-28-6.
Is Benzyl Isobutyrate used outside cosmetics?
Benzyl Isobutyrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Benzyl Isobutyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Good
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