Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Benzyl Isobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 other | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | other | rat | oral | REACH |
Expert Verdict
Cramer Class I with low toxicological concern. Not genotoxic and not phototoxic; adequate safety margins established.
Regulatory Flags
Frequently Asked Questions
Is Benzyl Isobutyrate safe in cosmetics?
Cramer Class I with low toxicological concern. Not genotoxic and not phototoxic; adequate safety margins established. The EU classifies Benzyl Isobutyrate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Benzyl Isobutyrate allowed in the EU?
Benzyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzyl Isobutyrate do in cosmetics?
Benzyl Isobutyrate functions as: Perfuming / Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-28-6.
What is the Margin of Safety for Benzyl Isobutyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Benzyl Isobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Benzyl Isobutyrate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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