Good Cosmetic Ingredient NOAEL Data

Benzyl Isovalerate

INCI: BENZYL ISOVALERATE

CAS Number
103-38-8
Function
Perfuming (heavy floral fragrance)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FEMA GRAS for food use; permitted in cosmetics as fragrance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Benzyl Isovalerate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day other rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 500 other oral rat oral REACH

Expert Verdict

Standard fragrance-level use supported with adequate margin of safety.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Benzyl Isovalerate safe in cosmetics?

Standard fragrance-level use supported with adequate margin of safety. The EU classifies Benzyl Isovalerate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is Benzyl Isovalerate allowed in the EU?

Benzyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Benzyl Isovalerate do in cosmetics?

Benzyl Isovalerate functions as: Perfuming (heavy floral fragrance). It is classified as a cosmetic ingredient in our database. CAS number: 103-38-8.

What is the Margin of Safety for Benzyl Isovalerate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Benzyl Isovalerate?

The NOAEL (No Observed Adverse Effect Level) for Benzyl Isovalerate is 1000 mg/kg bw/day based on a oral study via other route in rat. A total of 3 study endpoints are available. Source: REACH.

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