Is Benzyl Propionate safe in cosmetics?
Benzyl Propionate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Benzyl Propionate
Also known as: Propanoic acid, phenylmethyl ester, EINECS 204-559-3, FEMA No. 2150, NSC 46100, Phenylmethyl propanoate (+3 more)
Benzyl Propionate (CAS 122-63-4) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 122-63-4 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring and nutrient; Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
EC Number
204-559-3
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzyl Propionate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Benzyl Propionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Benzyl Propionate across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for Benzyl Propionate based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS"}
fragrance_ifra
{"cas_number": "122-63-4", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.11", "ifra_max_use_level_category_4_pct": "1.8", "ifra_max_use_level_category_7_pct": "0.26", "ifra_max_use_level_category_11_pct": "0.052", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Benzyl Propionate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Benzyl Propionate by CAS number or substance name.
Studies
2
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Propanoic acid, phenylmethyl ester
EINECS 204-559-3
FEMA No. 2150
NSC 46100
Phenylmethyl propanoate
Phenylmethyl propionate
Propionic acid, benzyl ester
UNII-307DN1208L
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185609
Frequently Asked Questions
Is Benzyl Propionate allowed in the EU?
Benzyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzyl Propionate do in cosmetics?
Benzyl Propionate functions as: Flavouring and nutrient; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 122-63-4.
What is the NOAEL for Benzyl Propionate?
The NOAEL (No Observed Adverse Effect Level) for Benzyl Propionate is =500 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Benzyl Propionate used outside cosmetics?
Benzyl Propionate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Benzyl Propionate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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