Moderate Cosmetic Ingredient NOAEL Data Sensitization Data

Benzyl Propionate

CAS Number
122-63-4
Function
Flavouring and nutrient; Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Benzyl Propionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 500 mg/kg bw/day oral rat oral REACH
NOAEL 500 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 13 ppm 1991 rat inhalation REACH
NOAEL 13 ppm 1991 rat inhalation REACH
LOAEL 50000 ppm oral rat oral REACH
LOAEL 12000 ppm oral rat oral REACH
NOAEL 520.25 mg/kg bw/day oral rat oral REACH

Sensitization Profile

Contact sensitization data for Benzyl Propionate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS

Expert Verdict

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Benzyl Propionate safe in cosmetics?

Benzyl Propionate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.

Is Benzyl Propionate allowed in the EU?

Benzyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Benzyl Propionate do in cosmetics?

Benzyl Propionate functions as: Flavouring and nutrient; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 122-63-4.

What is the Margin of Safety for Benzyl Propionate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Benzyl Propionate?

The NOAEL (No Observed Adverse Effect Level) for Benzyl Propionate is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.

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