Butenediol

INCI: BUTENEDIOL

CAS Number
110-64-5 (2-Butene-1,4-diol)
Function
Humectant, Solvent, Skin Conditioning Agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Insufficient data โ€” No published MoS; concentration-of-use data needed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Metabolized in vivo to 1,4-butanediol with potential GBL/GHB precursor concern; CIR flagged insufficient data for the saturated analogue; 28-day dermal toxicity data needed.

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Concern Level: High

Frequently Asked Questions

Is Butenediol safe in cosmetics?

Metabolized in vivo to 1,4-butanediol with potential GBL/GHB precursor concern; CIR flagged insufficient data for the saturated analogue; 28-day dermal toxicity data needed. The EU classifies Butenediol as "permitted". Safety rating: MODERATE.

Is Butenediol allowed in the EU?

Butenediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Butenediol do in cosmetics?

Butenediol functions as: Humectant, Solvent, Skin Conditioning Agent. It is classified as a cosmetic ingredient in our database. CAS number: 110-64-5 (2-Butene-1,4-diol).

What is the Margin of Safety for Butenediol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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