Is Calcium Hydroxymethionine safe in cosmetics?
Calcium Hydroxymethionine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Calcium Hydroxymethionine
Also known as: Calcium bis((1)-2-hydroxy-4-(methylthio)butyrate), Butanoic acid, 2-hydroxy-4-(methylthio)-, calcium salt (2:1), Calcium DL-2-hydroxy-4-methylthiobutyrate, Calcium DL-alpha-hydroxy-gamma-methylthiobutyrate, Calcium alpha-hydroxy-gamma-methylmercaptobutyrate (+8 more)
INCI: CALCIUM HYDROXYMETHIONINE
Calcium Hydroxymethionine (CAS 4857-44-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning (calcium salt of. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Function
Skin conditioning, hair conditioning (calcium salt of 2-hydroxy-4-(methylthio)butanoic acid)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
calcium bis(2-hydroxy-4-methylsulfanylbutanoate)
InChIKey
ABRVDWASZFDIEH-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Insufficient cosmetic-specific data to calculate MoS; EFSA oral ADI data available but dermal extrapolation needed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Hydroxymethionine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Editorial summary
Preliminary editorial summary for Calcium Hydroxymethionine — not a computed safety verdict. See the sourced toxicological data above.
Known Synonyms
Calcium bis((1)-2-hydroxy-4-(methylthio)butyrate)
Butanoic acid, 2-hydroxy-4-(methylthio)-, calcium salt (2:1)
Calcium DL-2-hydroxy-4-methylthiobutyrate
Calcium DL-alpha-hydroxy-gamma-methylthiobutyrate
Calcium alpha-hydroxy-gamma-methylmercaptobutyrate
D-L-alpha-Hydroxylmethionine calcium
DL-Methioninehydroxyanalog calcium
Methionine hydroxyl analog calcium salt
2-Hydroxy-4-(methylthio)butyric acid calcium salt
Hydan
Hydan (methionine hydroxy analog)
MHA
MHA-84
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Calcium Hydroxymethionine allowed in the EU?
Calcium Hydroxymethionine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Hydroxymethionine do in cosmetics?
Calcium Hydroxymethionine functions as: Skin conditioning, hair conditioning (calcium salt of 2-hydroxy-4-(methylthio)butanoic acid). It is classified as a cosmetic ingredient in our database. CAS number: 4857-44-7.
Is Calcium Hydroxymethionine used outside cosmetics?
Calcium Hydroxymethionine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Hydroxymethionine compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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