Calcium Hydroxymethionine

INCI: CALCIUM HYDROXYMETHIONINE

CAS Number
4857-44-7
Function
Skin conditioning, hair conditioning (calcium salt of 2-hydroxy-4-(methylthio)butanoic acid)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Insufficient cosmetic-specific data to calculate MoS; EFSA oral ADI data available but dermal extrapolation needed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Data gap โ€” no published HRIPT, dermal irritation, or phototoxicity studies specific to cosmetic use. Formulator must generate or source safety data for CPSR. Sulfur-containing compound โ€” verify odor stability.

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Concern Level: Moderate

Frequently Asked Questions

Is Calcium Hydroxymethionine safe in cosmetics?

Data gap โ€” no published HRIPT, dermal irritation, or phototoxicity studies specific to cosmetic use. Formulator must generate or source safety data for CPSR. Sulfur-containing compound โ€” verify odor stability. The EU classifies Calcium Hydroxymethionine as "permitted". Safety rating: MODERATE.

Is Calcium Hydroxymethionine allowed in the EU?

Calcium Hydroxymethionine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Calcium Hydroxymethionine do in cosmetics?

Calcium Hydroxymethionine functions as: Skin conditioning, hair conditioning (calcium salt of 2-hydroxy-4-(methylthio)butanoic acid). It is classified as a cosmetic ingredient in our database. CAS number: 4857-44-7.

What is the Margin of Safety for Calcium Hydroxymethionine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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