Is Calcium Sulfate Hydrate safe in cosmetics?
Calcium Sulfate Hydrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Calcium Sulfate Hydrate
INCI: CALCIUM SULFATE HYDRATE
Calcium Sulfate Hydrate (CAS 10101-41-4) is a cosmetic cosmetic ingredient functioning as Abrasive, Astringent, Anticaking, Binding, Bleaching, Opacifying, Skin. NOAEL 0.65 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 10101-41-4 →
Auto-generated CPSR Part A draft with source citations
Function
Abrasive, Astringent, Anticaking, Binding, Bleaching, Opacifying, Skin Conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
calcium;sulfate;dihydrate
InChIKey
PASHVRUKOFIRIK-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate — No systemic exposure concern
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Sulfate Hydrate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Hazard Statements
No hazard classification according to GHS criteria
Short-term Exposure Effects
May cause mechanical irritation.
Long-term Exposure Effects
Lungs may be affected by repeated or prolongated exposure to dust particles.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Calcium Sulfate Hydrate across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1734
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Sulfate Hydrate.
Chemical Function
Binder
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
inert_ingredient; non_food_use; Pesticides
inert_ingredient; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Calcium Sulfate Hydrate allowed in the EU?
Calcium Sulfate Hydrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Sulfate Hydrate do in cosmetics?
Calcium Sulfate Hydrate functions as: Abrasive, Astringent, Anticaking, Binding, Bleaching, Opacifying, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 10101-41-4.
Compliance Tools
Check Calcium Sulfate Hydrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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