Calendula Officinalis Meristem Cell Extract

INCI: CALENDULA OFFICINALIS MERISTEM CELL EXTRACT

CAS Number
Not assigned (plant stem cell derivative)
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not established. Requires dedicated characterization data.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel biotech ingredient with meristem cell extracts derived from undifferentiated tissue cultures; CIR Calendula coverage does not extend to this derivative. Compositional analysis including sesquiterpene lactone profiling is strongly recommended before CPSR submission due to potential Asteraceae cross-reactivity.

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Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Calendula Officinalis Meristem Cell Extract safe in cosmetics?

Novel biotech ingredient with meristem cell extracts derived from undifferentiated tissue cultures; CIR Calendula coverage does not extend to this derivative. Compositional analysis including sesquiterpene lactone profiling is strongly recommended before CPSR submission due to potential Asteraceae cross-reactivity. The EU classifies Calendula Officinalis Meristem Cell Extract as "restricted". Safety rating: MODERATE.

Is Calendula Officinalis Meristem Cell Extract allowed in the EU?

Calendula Officinalis Meristem Cell Extract EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Calendula Officinalis Meristem Cell Extract do in cosmetics?

Calendula Officinalis Meristem Cell Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (plant stem cell derivative).

What is the Margin of Safety for Calendula Officinalis Meristem Cell Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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