Good Emollient

Caprylyl Methicone

INCI: CAPRYLYL METHICONE

CAS Number
17955-88-3
Function
emollient, volatile carrier, skin-conditioning, D5 replacement
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA restriction; non-mutagenic per OECD TG 471; oral and dermal LD50 >2,000 mg/kg in rat studies (CIR data)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Leading volatile linear silicone replacement for D5 (cyclopentasiloxane) following EU Reg 2024/1328 enforcement in June 2026. MW 335, bp 263°C, log P = 9 with excellent cosmetic volatile carrier properties without the vPvB environmental classification of cyclic siloxanes. Non-mutagenic, low acute toxicity (LD50 >2,000 mg/kg). Dermal penetration unlikely. Widely adopted in reformulated hair care and skin care as the primary cyclic siloxane substitute.

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Concern Level: None

Regulatory Flags

d5-alternative volatile-silicone linear-silicone non-cyclic cir-approved genotoxicity-negative cosmos-restricted

Frequently Asked Questions

Is Caprylyl Methicone safe in cosmetics?

Leading volatile linear silicone replacement for D5 (cyclopentasiloxane) following EU Reg 2024/1328 enforcement in June 2026. MW 335, bp 263°C, log P = 9 with excellent cosmetic volatile carrier properties without the vPvB environmental classification of cyclic siloxanes. Non-mutagenic, low acute toxicity (LD50 >2,000 mg/kg). Dermal penetration unlikely. Widely adopted in reformulated hair care and skin care as the primary cyclic siloxane substitute. The EU classifies Caprylyl Methicone as "permitted". Safety rating: GOOD.

Is Caprylyl Methicone allowed in the EU?

Caprylyl Methicone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Caprylyl Methicone do in cosmetics?

Caprylyl Methicone functions as: emollient, volatile carrier, skin-conditioning, D5 replacement. It is classified as a Emollient in our database. CAS number: 17955-88-3.

What is the Margin of Safety for Caprylyl Methicone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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