Is Celestolide safe in cosmetics?
Celestolide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Celestolide
Also known as: Ethanone, 1-[6-(1,1-dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl]-, 4-Acetyl-6-butyl-1,1-dimethylindane, 6-tert-Butyl-1,1-dimethyl-4-indanyl methyl ketone, 1-(6-(1,1-Dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl)ethanone, EINECS 236-114-4 (+4 more)
INCI: CELESTOLIDE
Celestolide (CAS 13171-00-1) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 13171-00-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Celestolide is prohibited in EU cosmetics but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(6-tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)ethanone
InChIKey
IKTHMQYJOWTSJO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not restricted; permitted as fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Celestolide.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (limited)
LOEC: 10 µM
EU status: allowed
weak modulator
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (1)
JECFA Number
812
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Celestolide.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Ethanone, 1-[6-(1,1-dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl]-
4-Acetyl-6-butyl-1,1-dimethylindane
6-tert-Butyl-1,1-dimethyl-4-indanyl methyl ketone
1-(6-(1,1-Dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl)ethanone
EINECS 236-114-4
FEMA No. 3653
Ketone, 6-tert-butyl-1,1-dimethyl-4-indanyl methyl
UNII-E1HM68Q21P
1-(6-tert-Butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)ethanone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188960
Frequently Asked Questions
Is Celestolide allowed in the EU?
Celestolide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Celestolide do in cosmetics?
Celestolide functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 13171-00-1.
Is Celestolide used outside cosmetics?
Celestolide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Celestolide have different safety status in cosmetics vs industrial chemicals?
Celestolide is prohibited in EU cosmetics but has active industrial GHS classifications.
Compliance Tools
Check Celestolide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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