Moderate Cosmetic Ingredient

Centella Asiatica Leaf Extract

INCI: CENTELLA ASIATICA LEAF EXTRACT

CAS Number
84696-21-9
Function
Skin Conditioning — Miscellaneous
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not an FDA-approved drug; permitted as a cosmetic ingredient under FD&C Act; not in the GRASE monograph system

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Weak sensitization potential in susceptible individuals; reproductive toxicity in male rats at oral doses not relevant at cosmetic topical levels; asiaticoside classified as weak tumor promoter in mouse skin painting studies

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Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen

Frequently Asked Questions

Is Centella Asiatica Leaf Extract safe in cosmetics?

Weak sensitization potential in susceptible individuals; reproductive toxicity in male rats at oral doses not relevant at cosmetic topical levels; asiaticoside classified as weak tumor promoter in mouse skin painting studies The EU classifies Centella Asiatica Leaf Extract as "permitted". Safety rating: MODERATE.

Is Centella Asiatica Leaf Extract allowed in the EU?

Centella Asiatica Leaf Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Centella Asiatica Leaf Extract do in cosmetics?

Centella Asiatica Leaf Extract functions as: Skin Conditioning — Miscellaneous. It is classified as a cosmetic ingredient in our database. CAS number: 84696-21-9.

What is the Margin of Safety for Centella Asiatica Leaf Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Centella Asiatica Leaf Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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