Is Ceramide 3 safe in cosmetics?
Ceramide 3 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Ceramide 3
INCI: CERAMIDE NP
Ceramide 3 (CAS 100403-19-8 / 72968-43-5) is a cosmetic cosmetic ingredient functioning as Hair conditioning, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 100403-19-8 / 72968-43-5 →
Auto-generated CPSR Part A draft with source citations
Function
Hair conditioning, skin conditioning
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
359 formulations in VCRP (second highest among ceramides); max concentration 0.2% in lipstick and face/neck care
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ceramide 3.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Ceramide 3, relevant to systemic exposure and MoS calculations.
Absorption %
3-8%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
537.9 Da
Log P
9.5
Systemic Absorption
minimal
Topical Bioavailability
2-6%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Int J Cosmet Sci 2010
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 3 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "100403-19-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "100403-19-8", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5/urban_pollutants/TEWL", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation…
baby_pediatric
{"cas_number": "100403-19-8", "ingredient_class": "moisturizer_baby", "pediatric_safety_rating": "excellent", "minimum_age_months": "3", "neonatal_safe": "yes", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Biomimetic lipid, barrier repair, increasingly used pediatric AD", "transepidermal_absorption_risk_pediatric": "very_low", "dose_per_kg_body_weight_conce…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,sensitive,combination,normal,mature,rosacea", "acne_safe": "yes", "source": "Skin-identical lipid"}
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.0", "product_type": "Cleanser", "function_at_concentration": "Barrier protection", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "450", "estimated_cost_per_kg_usd_high": "850", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "Japan/Europe", "bulk_discount_threshold_kg": "5", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Ceramid…
dermal_absorption
{"molecular_weight_da": "537.9", "log_p_value": "9.5", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum", "absorption_pct": "3-8", "systemic_absorption": "minimal", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "2-6", "safety_margin_factor": "low", "source":…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "emulsifier_type": "w_o", "emulsion_stabilization_mechanism": "steric_stabilization", "co_emulsifier_pairs": "cholesterol,phytosterols", "optimal_oil_phase_pct": "55-85", "optimal_water_phase_pct": "15-45", "droplet_size_range_um": "3-35", "creaming_resistance": "moderate", "coalescence_resistance": "excellent", "ostwald_ripening_resistance": "excellent", "free…
Expert Verdict
Expert safety assessment and concern-level summary for Ceramide 3.
Regulatory Flags
potential-allergen
Frequently Asked Questions
Is Ceramide 3 allowed in the EU?
Ceramide 3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ceramide 3 do in cosmetics?
Ceramide 3 functions as: Hair conditioning, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 100403-19-8 / 72968-43-5.
Compliance Tools
Check Ceramide 3 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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