Is Ceramide AP safe in cosmetics?
Ceramide AP has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Ceramide AP
INCI: CERAMIDE AP
Ceramide AP (CAS 154756-45-3) is a cosmetic cosmetic ingredient functioning as Ceramide barrier lipid, skin-conditioning agent. Part of. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 154756-45-3 →
Function
Ceramide barrier lipid, skin-conditioning agent. Part of ceramide:cholesterol:fatty acid triple-lipid system. Strengthens skin barrier, reduces water loss, supports healthy skin.
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR 2020 safe as used. Commercial supply synthetic or biotech-derived. BSE restriction does not apply.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ceramide AP.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Ceramide AP, relevant to systemic exposure and MoS calculations.
Absorption %
2-6%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
630.0 Da
Log P
10.2
Systemic Absorption
minimal
Topical Bioavailability
1-4%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: J Lipid Res 2014
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 3 | CIR Safety Assessment |
Editorial summary
Preliminary editorial summary for Ceramide AP — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
barrier-lipid
ceramide
alpha-hydroxy-ceramide
phytosphingosine-backbone
trilipid-triad
3:1:1-elias-ratio
atopic-dermatitis-target
scorad-improvement
steroid-sparing
peds-fda-510k
cir-reviewed
Frequently Asked Questions
Is Ceramide AP allowed in the EU?
Ceramide AP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ceramide AP do in cosmetics?
Ceramide AP functions as: Ceramide barrier lipid, skin-conditioning agent. Part of ceramide:cholesterol:fatty acid triple-lipid system. Strengthens skin barrier, reduces water loss, supports healthy skin.. It is classified as a cosmetic ingredient in our database. CAS number: 154756-45-3.
Compliance Tools
Check Ceramide AP compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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