Is Ceramide NP safe in cosmetics?
Ceramide NP has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Ceramide NP
Also known as: Ceramides, N-Acylsphingosine, N-Acylsphingosines, Synthetic ceramide, Synthetic ceramides (+1 more)
Ceramide NP (CAS 100403-19-8) is a cosmetic cosmetic ingredient functioning as Skin-conditioning agent, ceramide barrier lipid, phytosphingosine-backbone. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 100403-19-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent, ceramide barrier lipid, phytosphingosine-backbone ceramide. Critical trilipid-triad component (ceramide:cholesterol:fatty acid 3:1:1 ratio). Barrier repair, TEWL reduction, atopic dermatitis target.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 39(S3):5-25,2020
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ceramide NP.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Ceramide NP, relevant to systemic exposure and MoS calculations.
Absorption %
3-8%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
537.9 Da
Log P
9.5
Systemic Absorption
minimal
Topical Bioavailability
2-6%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Int J Cosmet Sci 2010
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 3 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "100403-19-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "100403-19-8", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5/urban_pollutants/TEWL", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation…
baby_pediatric
{"cas_number": "100403-19-8", "ingredient_class": "moisturizer_baby", "pediatric_safety_rating": "excellent", "minimum_age_months": "3", "neonatal_safe": "yes", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Biomimetic lipid, barrier repair, increasingly used pediatric AD", "transepidermal_absorption_risk_pediatric": "very_low", "dose_per_kg_body_weight_conce…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,sensitive,combination,normal,mature,rosacea", "acne_safe": "yes", "source": "Skin-identical lipid"}
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.0", "product_type": "Cleanser", "function_at_concentration": "Barrier protection", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "450", "estimated_cost_per_kg_usd_high": "850", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "Japan/Europe", "bulk_discount_threshold_kg": "5", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Ceramid…
dermal_absorption
{"molecular_weight_da": "537.9", "log_p_value": "9.5", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum", "absorption_pct": "3-8", "systemic_absorption": "minimal", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "2-6", "safety_margin_factor": "low", "source":…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "emulsifier_type": "w_o", "emulsion_stabilization_mechanism": "steric_stabilization", "co_emulsifier_pairs": "cholesterol,phytosterols", "optimal_oil_phase_pct": "55-85", "optimal_water_phase_pct": "15-45", "droplet_size_range_um": "3-35", "creaming_resistance": "moderate", "coalescence_resistance": "excellent", "ostwald_ripening_resistance": "excellent", "free…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Regulatory List Membership (2)
EU Regulated in Personal Care
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Ceramide NP.
Regulatory Flags
barrier-lipid
ceramide
phytosphingosine-backbone
trilipid-triad
3:1:1-elias-ratio
atopic-dermatitis-target
scorad-improvement
non-inferior-to-corticosteroid
steroid-sparing
peds-fda-510k
cir-reviewed
bse-source-check
Known Synonyms
Ceramides
N-Acylsphingosine
N-Acylsphingosines
Synthetic ceramide
Synthetic ceramides
EC No.: 309-560-3
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Europe; Personal care
Europe; Personal care
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is Ceramide NP allowed in the EU?
Ceramide NP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ceramide NP do in cosmetics?
Ceramide NP functions as: Skin-conditioning agent, ceramide barrier lipid, phytosphingosine-backbone ceramide. Critical trilipid-triad component (ceramide:cholesterol:fatty acid 3:1:1 ratio). Barrier repair, TEWL reduction, atopic dermatitis target.. It is classified as a cosmetic ingredient in our database. CAS number: 100403-19-8.
Compliance Tools
Check Ceramide NP compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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