Is Cetonal safe in cosmetics?
Cetonal has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Cetonal
Also known as: EINECS 265-747-9, 2-Methyl-4-(2,6,6-trimethyl-2(1)-cyclohexen-1-yl) butanal, 2-Methyl-4-(2,6,6-trimethyl-2-cyclohexenyl)butanal, alpha,2,2,6-Tetramethylcyclohexenebutanal, 4-(2,6,6-Trimethyl-2(and/or 3)-cyclohexene)-2-methylbutanal
INCI: METHYL GAMMA ISOMETHYL IONONE
Cetonal (CAS 65405-84-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with woody, orris, leather, and tobacco accords. Use level. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 65405-84-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with woody, orris, leather, and tobacco accords. Use level 0.1-2% in fragrance concentrates.
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-(2,6,6-trimethylcyclohex-2-en-1-yl)pentanal
InChIKey
ACVNYUMGXUDACR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted as a fragrance ingredient. FDA does not require individual fragrance component disclosure on labels.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cetonal.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 107 | 0 | 1181 | 1181 | non-sensitizer |
| HMT | - | 0 | 18900 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Cetonal.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
EINECS 265-747-9
2-Methyl-4-(2,6,6-trimethyl-2(1)-cyclohexen-1-yl) butanal
2-Methyl-4-(2,6,6-trimethyl-2-cyclohexenyl)butanal
alpha,2,2,6-Tetramethylcyclohexenebutanal
4-(2,6,6-Trimethyl-2(and/or 3)-cyclohexene)-2-methylbutanal
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cetonal allowed in the EU?
Cetonal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cetonal do in cosmetics?
Cetonal functions as: Fragrance ingredient with woody, orris, leather, and tobacco accords. Use level 0.1-2% in fragrance concentrates.. It is classified as a cosmetic ingredient in our database. CAS number: 65405-84-7.
Is Cetonal used outside cosmetics?
Cetonal also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cetonal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Geranyloxyacetaldehyde
Moderate
Chemical family
Fragrance ingredient (aldehyde)
cis-3-Hexenyl Anthranilate
Good
Chemical family
Fragrance ingredient with fruity, gre...
cis-3-Hexenyl Salicylate
Moderate
Chemical family
Fragrance ingredient with green, herb...
Is Cetonal in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cetonal in your formulation.