Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Cetrimonium Methosulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | ca.100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 10 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 10 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | ca.113 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 113 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 45 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 45 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Methosulfate counterion is not explicitly restricted in EU Annexes; prudent assessors apply the same limits as the chloride form (up to 0.25% in leave-on products).
Frequently Asked Questions
Is Cetrimonium Methosulfate safe in cosmetics?
Methosulfate counterion is not explicitly restricted in EU Annexes; prudent assessors apply the same limits as the chloride form (up to 0.25% in leave-on products). The EU classifies Cetrimonium Methosulfate as "permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.
Is Cetrimonium Methosulfate allowed in the EU?
Cetrimonium Methosulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cetrimonium Methosulfate do in cosmetics?
Cetrimonium Methosulfate functions as: Antimicrobial, Antistatic, Hair Conditioning, Emulsifying. It is classified as a Surfactant in our database. CAS number: 65060-02-8.
What is the Margin of Safety for Cetrimonium Methosulfate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cetrimonium Methosulfate?
The NOAEL (No Observed Adverse Effect Level) for Cetrimonium Methosulfate is ca.100 mg/kg bw/day based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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