Excellent Surfactant NOAEL Data Sensitization Data Dermal Penetration

Coco-Glucoside

INCI: COCO-GLUCOSIDE

CAS Number
110615-47-9
Function
Surfactant; cleanser; emulsifier; foam booster
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR assessed alkyl glucosides as safe when formulated to be non-irritating. EWG rated 2. ECOCERT/COSMOS certifiable. Longer chain length (C8โ€“C16 coconut fraction) vs decyl glucoside provides denser, more stable foam.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Coco-Glucoside. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
LOEL 500 mg/kg bw/day oral rat oral REACH
LOEL 500 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Sensitization Profile

Contact sensitization data for Coco-Glucoside based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
surfactant
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
glucoside-group
Reaction Type
contact-dermatitis

Source: NACDG; IVDK; ESSCA

Dermal Penetration Profile

Skin absorption and penetration characteristics of Coco-Glucoside, relevant to systemic exposure and MoS calculations.

Absorption %
3-8%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
365.4 Da
Log P
1.5
Systemic Absorption
minimal
Topical Bioavailability
2-6%
Safety Margin Factor
low
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: CIR

Expert Verdict

Longer-chain APG variant (C8โ€“C16 coconut fraction) delivering lower CMC and enhanced foaming density compared to decyl glucoside (C10). Standard technique for optimizing foam profile in sulfate-free formulations. ECOCERT/COSMOS certified. CIR confirmed safe. Near-zero irritation. Outstanding biodegradability per OECD 301.

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Concern Level: None

Regulatory Flags

apg nonionic ecocert cosmos biodegradable sulfate-free mild epa_safer_alternative

Frequently Asked Questions

Is Coco-Glucoside safe in cosmetics?

Longer-chain APG variant (C8โ€“C16 coconut fraction) delivering lower CMC and enhanced foaming density compared to decyl glucoside (C10). Standard technique for optimizing foam profile in sulfate-free formulations. ECOCERT/COSMOS certified. CIR confirmed safe. Near-zero irritation. Outstanding biodegradability per OECD 301. The EU classifies Coco-Glucoside as "permitted". Safety rating: EXCELLENT. 5 toxicological study endpoint(s) are available in our database.

Is Coco-Glucoside allowed in the EU?

Coco-Glucoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Coco-Glucoside do in cosmetics?

Coco-Glucoside functions as: Surfactant; cleanser; emulsifier; foam booster. It is classified as a Surfactant in our database. CAS number: 110615-47-9.

What is the Margin of Safety for Coco-Glucoside?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Coco-Glucoside?

The NOAEL (No Observed Adverse Effect Level) for Coco-Glucoside is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.

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