Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Disodium Cocoamphodiacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 53 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Amphodiacetate amphoteric surfactant — one of the mildest surfactant classes for cosmetic use. Paired with sodium lauroamphoacetate and APG glucosides in baby and tearless shampoo formulations achieving effective cleansing at pH 5.5–6.5 with near-zero eye irritation scores.
Regulatory Flags
Frequently Asked Questions
Is Disodium Cocoamphodiacetate safe in cosmetics?
Amphodiacetate amphoteric surfactant — one of the mildest surfactant classes for cosmetic use. Paired with sodium lauroamphoacetate and APG glucosides in baby and tearless shampoo formulations achieving effective cleansing at pH 5.5–6.5 with near-zero eye irritation scores. The EU classifies Disodium Cocoamphodiacetate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Disodium Cocoamphodiacetate allowed in the EU?
Disodium Cocoamphodiacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Cocoamphodiacetate do in cosmetics?
Disodium Cocoamphodiacetate functions as: Surfactant; co-surfactant; mildness modifier. It is classified as a Surfactant in our database. CAS number: 68650-39-5.
What is the Margin of Safety for Disodium Cocoamphodiacetate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Disodium Cocoamphodiacetate?
The NOAEL (No Observed Adverse Effect Level) for Disodium Cocoamphodiacetate is 53 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
Check Disodium Cocoamphodiacetate compliance across multiple jurisdictions:
Related Ingredients
Is Disodium Cocoamphodiacetate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Disodium Cocoamphodiacetate in your formulation.