Chlorhexidine Dihydrochloride

INCI: CHLORHEXIDINE DIHYDROCHLORIDE

CAS Number
3697-42-5
Function
Preservative, antimicrobial (oral care, skin antisepsis)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 0.3%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA: permitted in OTC drug products and cosmetics; monographed antimicrobial

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

ECHA identified need for further EU regulatory risk management; contact allergy increasing; anaphylaxis risk with mucosal exposure

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Concern Level: Moderate

Regulatory Flags

preservative

Frequently Asked Questions

Is Chlorhexidine Dihydrochloride safe in cosmetics?

ECHA identified need for further EU regulatory risk management; contact allergy increasing; anaphylaxis risk with mucosal exposure The EU classifies Chlorhexidine Dihydrochloride as "permitted". Safety rating: MODERATE.

Is Chlorhexidine Dihydrochloride allowed in the EU?

Chlorhexidine Dihydrochloride EU regulatory status: permitted. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.

What does Chlorhexidine Dihydrochloride do in cosmetics?

Chlorhexidine Dihydrochloride functions as: Preservative, antimicrobial (oral care, skin antisepsis). It is classified as a cosmetic ingredient in our database. CAS number: 3697-42-5.

What is the Margin of Safety for Chlorhexidine Dihydrochloride?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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