Is Chloroxylenol safe in cosmetics?
Chloroxylenol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Chloroxylenol
INCI: CHLOROXYLENOL
Chloroxylenol (CAS 88-04-0) is a cosmetic cosmetic ingredient functioning as Antimicrobial preservative. EU Regulation 1223/2009 status: permitted, max 0.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 88-04-0 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial preservative
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-chloro-3,5-dimethylphenol
InChIKey
OSDLLIBGSJNGJE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
CIR assessed safe as used (1985, reaffirmed 2006); currently under re-review (2022); FDA does not specifically restrict; max use concentration reported at 0.5%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chloroxylenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Chloroxylenol.
Regulatory Flags
preservative
ifra_fragrance
eu_cosing_listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHLOROXYLENOL
ChEMBL ID
CHEMBL398440
Max Phase
2
Adverse Event Associations
268
Frequently Asked Questions
Is Chloroxylenol allowed in the EU?
Chloroxylenol EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Chloroxylenol do in cosmetics?
Chloroxylenol functions as: Antimicrobial preservative. It is classified as a cosmetic ingredient in our database. CAS number: 88-04-0.
Is Chloroxylenol used outside cosmetics?
Chloroxylenol also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Chloroxylenol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Is Chloroxylenol in Your Products?
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Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Chloroxylenol in your formulation.