Good Cosmetic Ingredient Sensitization Data

Chloroxylenol

INCI: CHLOROXYLENOL

CAS Number
88-04-0
Function
Antimicrobial preservative
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 0.5%
🇺🇸 US Status permitted
US Notes CIR assessed safe as used (1985, reaffirmed 2006); currently under re-review (2022); FDA does not specifically restrict; max use concentration reported at 0.5%

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Chloroxylenol based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis

Source: ESSCA; IVDK; NACDG

Expert Verdict

Positive mutagenicity assay (clastogenic with S9 activation); positive estrogenic activity in vitro (ER-binding assay); testicular toxicity in rats at ≥100 mg/kg/d oral; ocular irritant (Category 1 in rabbits at 100%); case reports of contact depigmentation

⚠️
Concern Level: High

Regulatory Flags

preservative ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is Chloroxylenol safe in cosmetics?

Positive mutagenicity assay (clastogenic with S9 activation); positive estrogenic activity in vitro (ER-binding assay); testicular toxicity in rats at ≥100 mg/kg/d oral; ocular irritant (Category 1 in rabbits at 100%); case reports of contact depigmentation The EU classifies Chloroxylenol as "permitted". Safety rating: GOOD.

Is Chloroxylenol allowed in the EU?

Chloroxylenol EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Chloroxylenol do in cosmetics?

Chloroxylenol functions as: Antimicrobial preservative. It is classified as a cosmetic ingredient in our database. CAS number: 88-04-0.

What is the Margin of Safety for Chloroxylenol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Chloroxylenol compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Ammonium Silver Zinc Aluminum Silicate
Moderate
Ammonium Phenolsulfonate
Moderate
Tripotassium Phosphate
Good
Carnosic Acid
Moderate
Bromochlorophene
Moderate
Browse all 30,000+ ingredients →
📱

Is Chloroxylenol in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Chloroxylenol in your formulation.

Ingredient Decoder MoS Calculator