Is CI 18050 safe in cosmetics?
CI 18050 has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 9 toxicological study endpoint(s) are available in our database.
CI 18050
Also known as: 2,7-Naphthalenedisulfonic acid, 5-(acetylamino)-4-hydroxy-3-(phenylazo)-, disodium salt, C.I. 18050, 2,7-Naphthalenedisulfonic acid, 5-(acetylamino)-4-hydroxy-3-(2-phenyldiazenyl)-, sodium salt (1:2), EC No.: 223-098-9, C.I. Acid Red 1, disodium salt (+15 more)
CI 18050 (CAS 3734-67-6) is a cosmetic cosmetic ingredient functioning as Colorant. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 3734-67-6 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
disodium;5-acetamido-4-hydroxy-3-phenyldiazenylnaphthalene-2,7-disulfonate
InChIKey
WXLFIFHRGFOVCD-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not listed as an approved FDA color additive for cosmetics in the US; use would require FDA certification under 21 CFR; classified as Ext. D&C Red No. 11 in some contexts but not currently on FDA permitted list
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 18050.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for CI 18050. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =11.4 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =25 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =129 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =937.5 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1500 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =2000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =3000 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CI 18050 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Red
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
Product type: Not to be used in products applied on mucous membranes.
BRIN Brazil/India Cosmetics
India: Permitted Colorant
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
RED 2G | 2018 | 0-0.1 mg/kg bw | Not re-evaluated by JECFA, but the provisions for Red 2G was withdrawn at CCFA50. | TRS 669-JECFA 25/20 | FAS 16-JECFA 25/169
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Fragrance
Regulatory List Membership (3)
EU Regulated in Personal Care
IFRA Fragrance Transparency List
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 18050.
Regulatory Flags
azo-dye
eu-permitted
mucous-membrane-restriction
not-fda-approved
synthetic-colorant
allergen-potential
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 18050 by CAS number or substance name.
Studies
9
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
3000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2,7-Naphthalenedisulfonic acid, 5-(acetylamino)-4-hydroxy-3-(phenylazo)-, disodium salt
C.I. 18050
2,7-Naphthalenedisulfonic acid, 5-(acetylamino)-4-hydroxy-3-(2-phenyldiazenyl)-, sodium salt (1:2)
EC No.: 223-098-9
C.I. Acid Red 1, disodium salt
C.I. Food Red 10
Acetyl Red G
Acetyl Red J
Acetyl Rose 2GL
Acid Bright Red
Acid Brilliant Red
Acid Fast Red 3G
Acid Fast Red EGG
Acid Leather Red KG
Acid Naftol Red G
Acid Phloxine GA
Acid Red 2G
Acid Red GA
Acid Rose 2GL
Acidal Brilliant Red 2G
Chemical Function
Dye
Fragrance
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Red 2G
E Number
E128
ADI
0-0.1 mg/kg bw mg/kg bw
Food Category
colorant
Frequently Asked Questions
Is CI 18050 allowed in the EU?
CI 18050 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 18050 do in cosmetics?
CI 18050 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 3734-67-6.
What is the NOAEL for CI 18050?
The NOAEL (No Observed Adverse Effect Level) for CI 18050 is =10 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 9 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is CI 18050 used outside cosmetics?
CI 18050 also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 18050 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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