Is CI 21095 safe in cosmetics?
CI 21095 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
CI 21095
Also known as: Aaot Yellow, Atul Vulcan Fast Pigment Oil Yellow T, Benzidene Yellow G, Benzidene Yellow ABZ-249, Benzidine Yellow L (+15 more)
CI 21095 (CAS 5468-75-7) is a cosmetic cosmetic ingredient functioning as Colorant. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5468-75-7 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[[2-chloro-4-[3-chloro-4-[[1-(2-methylanilino)-1,3-dioxobutan-2-yl]diazenyl]phenyl]phenyl]diazenyl]-N-(2-methylphenyl)-3-oxobutanamide
InChIKey
LQZFGPJGXVFSTR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not listed as FDA-certified color additive for cosmetic use in US 21 CFR; use in cosmetics not established
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 21095.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for CI 21095. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Expert Verdict
Expert safety assessment and concern-level summary for CI 21095.
Regulatory Flags
azo-dye
pigment
diarylide
dcb-concern
not-fda-approved
eu-annex-iv
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 21095 by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Aaot Yellow
Atul Vulcan Fast Pigment Oil Yellow T
Benzidene Yellow G
Benzidene Yellow ABZ-249
Benzidine Yellow L
Benzidine Yellow AAOT
Benzidine Yellow ABZ 249
Benzidine Yellow GGT
Benzidine Yellow OT
Benzidine Yellow OTYA 8055
Calcotone Yellow GP
Diarylide Yellow AAOT
EINECS 226-789-3
Graphtol Yellow GXS
Hostaperm Yellow GT
Hostaperm Yellow GTT
Irgalite Yellow BR
Irgalite Yellow BRE
Isol Benzidine Yellow GO
Lake Yellow GA
Chemical Function
Pigment
Regulatory Lists
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Europe; plastic_additive
Europe
inert_ingredient; non_food_use; Pesticides
Europe; Toys and children's products
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 21095 allowed in the EU?
CI 21095 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 21095 do in cosmetics?
CI 21095 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 5468-75-7.
What is the NOAEL for CI 21095?
The NOAEL (No Observed Adverse Effect Level) for CI 21095 is =1000 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is CI 21095 used outside cosmetics?
CI 21095 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 21095 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
CI 40800 (Beta-Carotene)
Excellent
Same category
Colorant. Synthetic or naturally deri...
CI 75130 (Beta-Carotene)
Excellent
Same category
Colorant. Synthetic or plant-derived ...
CI 75170 (Guanine)
Excellent
Same category
Colorant. Natural crystalline materia...
CI 77004 (Kaolin)
Excellent
Same category
Colorant. Natural white clay mineral ...
CI 77007 (Ultramarine Blue)
Excellent
Same category
Colorant. Inorganic mineral pigment s...
CI 77019 (Mica)
Excellent
Same category
Colorant; Opacifying Agent; Bulking A...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
CI 10006
Moderate
Browse nearby
Colorant (green)
CI 10020
Moderate
Browse nearby
Colorant (green)
CI 10316 (Ext. D&C Yellow No. 7)
Moderate
Browse nearby
Colorant. Synthetic nitro dye (Disodi...
Is CI 21095 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CI 21095 in your formulation.