Moderate Cosmetic Ingredient NOAEL Data

CI 21100

CAS Number
5102-83-0
Function
Colorant (yellow disazo pigment)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status prohibited
US Notes Not FDA-listed for cosmetics; not among certified or exempt color additives.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for CI 21100. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 9000 ppm oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 9000 ppm oral rat oral REACH
NOAEL 500 mg/kg bw/day oral rat oral REACH

Expert Verdict

CI 21100 is a yellow disazo pigment with potential carcinogenic impurities (3,3'-dichlorobenzidine); restricted in EU for rinse-off use only and prohibited in US cosmetics due to lack of FDA approval.

⚠️
Concern Level: High

Regulatory Flags

colorant eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is CI 21100 safe in cosmetics?

CI 21100 is a yellow disazo pigment with potential carcinogenic impurities (3,3'-dichlorobenzidine); restricted in EU for rinse-off use only and prohibited in US cosmetics due to lack of FDA approval. The EU classifies CI 21100 as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.

Is CI 21100 allowed in the EU?

CI 21100 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 21100 do in cosmetics?

CI 21100 functions as: Colorant (yellow disazo pigment). It is classified as a cosmetic ingredient in our database. CAS number: 5102-83-0.

What is the Margin of Safety for CI 21100?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 21100?

The NOAEL (No Observed Adverse Effect Level) for CI 21100 is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.

Compliance Tools

Check CI 21100 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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