Is CI 21100 safe in cosmetics?
CI 21100 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: prohibited.
Moderate
Cosmetic Ingredient
CI 21100
Also known as: Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxo-, Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(2,4-dimethylphenyl)-3-oxo-, 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide], 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide, Benzidine Yellow 13 (+15 more)
CI 21100 (CAS 5102-83-0) is a cosmetic cosmetic ingredient functioning as Colorant (yellow disazo pigment). NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5102-83-0 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant (yellow disazo pigment)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[[2-chloro-4-[3-chloro-4-[[1-(2,4-dimethylanilino)-1,3-dioxobutan-2-yl]diazenyl]phenyl]phenyl]diazenyl]-N-(2,4-dimethylphenyl)-3-oxobutanamide
InChIKey
IAFBRPFISOTXSO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
prohibited
US Notes
Not FDA-listed for cosmetics; not among certified or exempt color additives.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 21100.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CI 21100 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1351
(EC) 2013/344
Annex IV — Permitted Colorants
Product type: Yellow
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1351
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
India: Permitted Colorant
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "D&C Yellow No. 7", "Chemical_Name": "Fluorescein", "CAS_Number": "518-47-8", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.707", "Notes": "Fluorescent dye"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 21100.
Regulatory Flags
colorant
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxo-
Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(2,4-dimethylphenyl)-3-oxo-
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide
Benzidine Yellow 13
Benzidine Yellow GR
C.I. 21100
Cromophtal Yellow HG
Discoall K 6820
Flexiverse Yellow YFD 1303
Hostafine Yellow GR
Irgalite Yellow B 3L
Irgalite Yellow BGW
Irgalite Yellow BKW
Irgalite Yellow LBG
Irgalite Yellow LBIW
Isol Benzidene Yellow GRX 2548
KET Yellow 405
Keystone Jet Print Micro Yellow
Lionol Yellow 1314
Chemical Function
Dye
Pigment
Regulatory Lists
banned; Europe; Personal care
Europe; plastic_additive
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 21100 allowed in the EU?
CI 21100 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 21100 do in cosmetics?
CI 21100 functions as: Colorant (yellow disazo pigment). It is classified as a cosmetic ingredient in our database. CAS number: 5102-83-0.
Is CI 21100 used outside cosmetics?
CI 21100 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 21100 compliance across multiple jurisdictions:
Ingredient Decoder
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Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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