Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for D&C Yellow No. 10 (Quinoline Yellow). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 8333 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 1500 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Permitted greenish-yellow dye with acceptable margin of safety values (235-1,174). Data gaps noted including unclear substance identity and rejected percutaneous absorption study.
Regulatory Flags
Frequently Asked Questions
Is D&C Yellow No. 10 (Quinoline Yellow) safe in cosmetics?
Permitted greenish-yellow dye with acceptable margin of safety values (235-1,174). Data gaps noted including unclear substance identity and rejected percutaneous absorption study. The EU classifies D&C Yellow No. 10 (Quinoline Yellow) as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is D&C Yellow No. 10 (Quinoline Yellow) allowed in the EU?
D&C Yellow No. 10 (Quinoline Yellow) EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does D&C Yellow No. 10 (Quinoline Yellow) do in cosmetics?
D&C Yellow No. 10 (Quinoline Yellow) functions as: Colorant, Hair Dyeing Agent. It is classified as a Colorant in our database. CAS number: 8004-92-0.
What is the Margin of Safety for D&C Yellow No. 10 (Quinoline Yellow)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for D&C Yellow No. 10 (Quinoline Yellow)?
The NOAEL (No Observed Adverse Effect Level) for D&C Yellow No. 10 (Quinoline Yellow) is 250 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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