Also known as: Prussian blue, CI 77510 Blue, Iron ferrocyanide (Fe4[Fe(CN)6]3), EC No.: 237-875-5, EINECS 237-875-5 (+12 more)
INCI: CI 77510
Ferric Ferrocyanide (Prussian Blue) (CAS 14038-43-8) is a cosmetic colorant functioning as Colorant (blue). Reported NOAEL =25 mg/kg bw/day in rat (2207; male/female) (FDA); EU Regulation 1223/2009 status: permitted, max Must be free from cyanide ions (purity condition). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 14038-43-8 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Ferric Ferrocyanide (Prussian Blue).
Calculate MoS for your specific formulation with the MoS Calculator.
5 study endpoints found for Ferric Ferrocyanide (Prussian Blue). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA |
| NOAEL | =25 mg/kg bw/day | oral | Rat | subchronic | ECHA |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| BR | permitted_colorant | - | Column 2: All products except eye area |
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Preliminary editorial summary for Ferric Ferrocyanide (Prussian Blue) — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Ferric Ferrocyanide (Prussian Blue) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Ferric Ferrocyanide (Prussian Blue) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: restricted. 5 toxicological study endpoint(s) are available in our database.
Ferric Ferrocyanide (Prussian Blue) EU regulatory status: permitted. Maximum allowed concentration: Must be free from cyanide ions (purity condition). This is based on EU Regulation 1223/2009 and its amendments.
Ferric Ferrocyanide (Prussian Blue) functions as: Colorant (blue). It is classified as a Colorant in our database. CAS number: 14038-43-8.
The NOAEL (No Observed Adverse Effect Level) for Ferric Ferrocyanide (Prussian Blue) is =25 mg/kg bw/day based on a repeated dose toxicity oral study via oral: feed route in rat (2207; male/female). A total of 5 study endpoints are available. Source: FDA.
Ferric Ferrocyanide (Prussian Blue) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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