Good Cosmetic Ingredient NOAEL Data GHS Classified

CI 74160

CAS Number
147-14-8
Function
Colorant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status prohibited
US Notes Not listed as an FDA-approved color additive for cosmetic use; no D&C or FD&C cosmetic designation in FDA tables. EU Annex IV-permitted for use in all cosmetics including non-eye area; approved in EU, China, and other markets but not cleared for US cosmetics by FDA.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for CI 74160. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=16000 mg/kg bw/day oral mouse oral REACH
NOAEL ca.4500 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Expert Verdict

Copper phthalocyanine blue pigment (Pigment Blue 15; CAS 147-14-8); EU Annex IV-permitted in all cosmetics; chemically stable, insoluble, low-absorption pigment with good safety profile; however, not approved by FDA for cosmetic use in the US.

⚠️
Concern Level: Low

Regulatory Flags

not-fda-approved eu-permitted phthalocyanine insoluble-pigment not-for-us-market eu_children_restricted eu_banned_cosmetics epa_safer_alternative ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is CI 74160 safe in cosmetics?

Copper phthalocyanine blue pigment (Pigment Blue 15; CAS 147-14-8); EU Annex IV-permitted in all cosmetics; chemically stable, insoluble, low-absorption pigment with good safety profile; however, not approved by FDA for cosmetic use in the US. The EU classifies CI 74160 as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is CI 74160 allowed in the EU?

CI 74160 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 74160 do in cosmetics?

CI 74160 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 147-14-8.

What is the Margin of Safety for CI 74160?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 74160?

The NOAEL (No Observed Adverse Effect Level) for CI 74160 is >=16000 mg/kg bw/day based on a oral study via oral route in mouse. A total of 4 study endpoints are available. Source: REACH.

Compliance Tools

Check CI 74160 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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